Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice

Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice

Author Silva, Regina Helena da Autor UNIFESP Google Scholar
Bellot, Rogerio Gentil Autor UNIFESP Google Scholar
Vital, Maria Aparecida Barbato Frazão Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
UNIV FED PARANA
Abstract The beneficial effects of monosialoganglioside GM1 (GM1) on learning and memory have been detected mostly in animals presenting genetic, lesion-induced or age-related memory deficits. The present study was carried out to investigate the effects of GM1 on the discriminative avoidance behavior of normal adult mice. EPM-M1 male mice were treated daily IP with 50 mg/kg GM1 or saline for 14 days. The discriminative avoidance conditioning was performed on day 15 in a modified elevated plus-maze. In one of the enclosed arms, the animals received aversive stimulation (light and noise). Tests were performed on days 20, 25 and 30 (tests 1, 2 and 3). The time the animals spent in each of the enclosed arms was recorded. In tests 1 and 2, GM1-treated mice spent less time in the aversive arm in comparison to the non-aversive enclosed arm. On the other hand, control animals spent a shorter time in the aversive arm only in test 1. The results suggest that the beneficial effects of GM1 on learning and memory can be observed in normal animals as well.
Keywords memory
ganglioside
GM1
discriminative avoidance behavior
mice
Language English
Date 1997-02-01
Published in Psychopharmacology. New York: Springer Verlag, v. 129, n. 4, p. 322-328, 1997.
ISSN 0033-3158 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 322-328
Access rights Closed access
Type Article
Web of Science ID WOS:A1997WM04300003
URI http://repositorio.unifesp.br/11600/45164

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