Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents

Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents

Author Freire, Sonia Maria de Farias Google Scholar
Emim, José Artur da Silva Autor UNIFESP Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Souccar, Caden Autor UNIFESP Google Scholar
Torres, Luce Maria Brandão Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
UNIV FED MARANHAO
Abstract The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.
Keywords SCOPARIA-DULCIS L
SCROPHULARIACEAE
MEDICINAL PLANT
GLUTINOL
ANALGESIC
ANTIINFLAMMATORY ACTIONS
RATS AND MICE
Language English
Date 1993-11-01
Published in Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993.
ISSN 0951-418X (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 408-414
Origin http://dx.doi.org/10.1002/ptr.2650070605
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1993ML69000004
URI http://repositorio.unifesp.br/11600/45112

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