Fructose-1,6-diphosphate: Potential protection in cyclosporine-induced renal impairment

Fructose-1,6-diphosphate: Potential protection in cyclosporine-induced renal impairment

Author Cardoso, Lucio Ronaldo Google Scholar
Santos, Oscar Fernando Pavão dos Autor UNIFESP Google Scholar
Boim, Mirian Aparecida Autor UNIFESP Google Scholar
Barros, Elvino José Guardião Google Scholar
Ajzen, Horacio Autor UNIFESP Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
FED UNIV RIO DE JANEIRO
UNIV FED RIO GRANDE SUL
Abstract There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine ifFDP also protects against cyclosporine (CsA)-induced nephrotoxicity, two groups of adult male Wistar rats were studied for whole kidney clearance rates. After two initial control periods, group 1 received only CsA (CsA, n = 8). Group 2 received FDP 350 mg/kg, followed by CsA 50 mg/kg (FDP-CsA, n = 6). In both groups, after a 30-min equilibration period, two additional clearance rates were measured (Post1 and Post2). A significant reduction in clearance rates was observed after drug infusion in both groups (approximately 58 and 64% in CsA and FDP-CsA groups, respectively, p < 0.05) with a recovery to control values in the Post2 period in the FDP-CsA group. These data suggest a protective effect of FDP on CsA-induced renal impairment.
Keywords nephrotoxicity
fructose-1,6-diphosphate
cyclosporine
acute renal failure
glomeruli
Language English
Date 1996-01-01
Published in Nephron. Basel: Karger, v. 72, n. 1, p. 67-71, 1996.
ISSN 0028-2766 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 67-71
Origin http://dx.doi.org/10.1159/000188808
Access rights Closed access
Type Article
Web of Science ID WOS:A1996TN97900009
URI http://repositorio.unifesp.br/11600/45001

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