Dopamine Transporter Imaging Using Tc-99m-TRODAT-1 SPECT in Parkinson's Disease

Dopamine Transporter Imaging Using Tc-99m-TRODAT-1 SPECT in Parkinson's Disease

Author Bor-Seng-Shu, Edson Google Scholar
Felício, André Carvalho Autor UNIFESP Google Scholar
Braga-Neto, Pedro Autor UNIFESP Google Scholar
Batista, Ilza Rosa Autor UNIFESP Google Scholar
Paiva, Wellingson Silva Google Scholar
Andrade, Daniel Ciampi de Google Scholar
Teixeira, Manoel Jacobsen Google Scholar
Franco de Andrade, Luiz Augusto Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Shih, Ming Chi Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Abstract Background: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients.Material/Methods: Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age-and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using Tc-99m-TRODAT-1.Results: PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal Tc-99m-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal Tc-99m-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal Tc-99m-TRODAT-1 binding values provided by different readers, contrary to Tc-99m-TRODAT-1 binding estimates in the caudate nucleus.Conclusions: Striatal DAT imaging using Tc-99m-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility.
Keywords Molecular Imaging
Parkinson Disease - radionuclide imaging
Tomography, Emission-Computed, Single-Photon
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-08-11
Published in Medical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 20, p. 1413-1418, 2014.
ISSN 1643-3750 (Sherpa/Romeo, impact factor)
Publisher Int Scientific Literature, Inc
Extent 1413-1418
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000341005300001

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