Randomized Controlled Trial of Iron-Fortified Drinking Water in Preschool Children

Randomized Controlled Trial of Iron-Fortified Drinking Water in Preschool Children

Author Arcanjo, Francisco Placido Nogueira Autor UNIFESP Google Scholar
Amancio, Olga Maria Silverio Autor UNIFESP Google Scholar
Braga, Josefina Aparecida Pellegrini Autor UNIFESP Google Scholar
Pinto, Vicente de Paulo Teixeira Google Scholar
Institution Free Univ Brussels
Prime Hlth Consultants Inc
Univ Pittsburgh
Baylor Univ
Univ Queensland
Hosp ABC Mexico
Miami Childrens Hosp
Universidade Federal de São Paulo (UNIFESP)
Inst Nacl Salud
Univ Seville
Ponce Sch Med
Univ Nebraska
Univ Hong Kong
Mead Johnson Res Ctr
Abstract Objectives: To evaluate the effects of fortified drinking water. with different concentrations of iron added, on hemoglobin and hematocrit values in preschoolers.Methods: Double-blind, randomized cluster clinical trial, with children aged 2 to 5 years of age, from 4 state-run schools, forming 1 group for each school. For fortification, ferrous sulphate in concentrations of 5 mg of elemental iron per liter of water (group A), 7.5 mg (group B), and 10 mg (group C), was used during a period of 4 months. In group D, the control, a placebo (Bixa orellana) was added. Hemoglobin and hematocrit values were checked before and after intervention.Results: Before fortification, hemoglobin and hematocrit averages were below the reference values adopted in all groups. After fortification, the prevalence of anemia showed a reduction in the 4 groups, which was more pronounced in group B, at 48.3%. The hemoglobin values in groups B (11.5) and C (11.4) were statistically similar. However, the average consumption of water/day/student was lower in group C. Comparison of hemoglobin values between groups A (11.2) and D (11.0) did not show a significant difference, suggesting insignificant efficacy with 5 mg Fe/L fortification.Conclusions: The consumption of drinking water fortified with 7.5 mg of elemental iron/L water resulted in greater adhesion and an increase in hemoglobin values, with a reduction in the prevalence of anemia.
Keywords iron
potable water
preschool children
hemoglobin
anemia
Language English
Sponsor FUNCAP-Fundacao Cearense de Apoio ao Desenvolvimento Cientifico
Date 2010-04-01
Published in Journal Of The American College Of Nutrition. Abingdon: Routledge Journals, Taylor & Francis Ltd, v. 29, n. 2, p. 122-129, 2010.
ISSN 0731-5724 (Sherpa/Romeo, impact factor)
Publisher Routledge Journals, Taylor & Francis Ltd
Extent 308-316
Origin http://dx.doi.org/10.1080/07315724.2010.10719825
Access rights Closed access
Type Article
Web of Science ID WOS:000281124600006
URI http://repositorio.unifesp.br/11600/44720

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