Leptin assessment in acute lymphocytic leukemia survivors: Role of cranial radiotherapy?

Leptin assessment in acute lymphocytic leukemia survivors: Role of cranial radiotherapy?

Author Siviero-Miachon, Adriana Aparecida Autor UNIFESP Google Scholar
Spinola-Castro, Angela Maria Autor UNIFESP Google Scholar
Tosta-Hernandez, Patricia Debora Cavalcanti Autor UNIFESP Google Scholar
Lee, Maria Lucia de Martino Google Scholar
Petrilli, Antonio Sergio Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Leptin has been hypothesized to play a role in the development of obesity in leukemia survivors, particularly those who have received cranial radiotherapy. This cross-sectional study evaluated the relationship between leptin levels and body mass index (BMI) in a sample of 26 acute lymphocytic leukemia survivors of both sexes, treated with and without cranial irradiation, aged 7.6 to 17 years, at a mean 3.4 +/- 2.0 years off treatment. There were significantly more males among the irradiated group (P < 0.001), even though no differences were encountered in pubertal stage (P = 1.000), BMI standard deviation score (mean SD) (0.68 +/- 1.00 vs. 1.19 +/- 0.78; P = 0.164), or leptin concentrations (17.01 +/- 17.04 vs. 23.3 +/- 13.4; P = 0.309). Nonetheless, there was a positive correlation between the natural logarithm of leptin and BMI standard deviation score [t(22) = 2.348, P = 0.028], however, no differences were recorded among irradiated and nonirradiated patients [F(2,22) = 0.384, P = 0.685]. When this relationship was compared between sexes, a significant difference was encountered [F(2,22) = 4.907, P 0.017], with males having the strongest association (R-males(2) = 65.5%, R-females(2) = 34.7% ).Leptin is a reliable adiposity index as it strongly correlates with BMI. Overall, the current data suggest that cranial irradiation did not play a role upon this relationship; however, sex differences influenced positively this correlation.
Keywords leptin
body weight
acute/radiotherapy and leukemia
acute/drug therapy
Language English
Date 2007-11-01
Published in Journal Of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 29, n. 11, p. 776-782, 2007.
ISSN 1077-4114 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 776-782
Origin http://dx.doi.org/10.1097/MPH.0b013e318159a545
Access rights Closed access
Type Article
Web of Science ID WOS:000251077300012
URI http://repositorio.unifesp.br/11600/44549

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