Low density neutrophils in patients with juvenile idiopathic arthritis

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dc.contributor.author Ronchezel, M. V.
dc.contributor.author Hacbarth, E. T.
dc.contributor.author Len, Claudio Arnaldo [UNIFESP]
dc.contributor.author Terreri, Maria Teresa [UNIFESP]
dc.contributor.author Andrade, LEC [UNIFESP]
dc.contributor.author Hilário, Maria Odete Esteves [UNIFESP]
dc.date.accessioned 2018-06-15T18:02:43Z
dc.date.available 2018-06-15T18:02:43Z
dc.date.issued 2003-01-01
dc.identifier.citation Journal Of Investigational Allergology And Clinical Immunology. Gottingen: Hogrefe & Huber Publishers, v. 13, n. 2, p. 103-107, 2003.
dc.identifier.issn 1018-9068
dc.identifier.uri http://repositorio.unifesp.br/11600/44463
dc.description.abstract Objectives: (1) To study the correlation among conventional clinical and laboratory parameters and the relation between the number of lymphocytes and neutrophils (L/N) in cell suspensions from peripheral blood of patients with juvenile idiopathic arthritis (JIA). (2) To evaluate the L/N relation of RA patients after an 8 year follow-up period. Methods: Fifty-one JIA patients (25 female, disease course: 19 systemic, 15 polyarticular, 17 pauciarticular) were enrolled in the study. To measure the L/N relation, we used Boyum's method: The leucocyte separation was done by centrifugation of peripheral blood on Ficoll-Hypaque (FH) gradient, and the number of lymphocytes, monocytes, and neutrophils in 500 cells was determined. The following clinical and laboratory parameters were evaluated: disease activity, number of active and limited joints, functional capacity, erythrocyte sedimentation rate (ESR), and C reactive protein (CRP). Twenty-four healthy children were used as controls. We also studied 13/51 patients from our Pediatric Rheumatology Unit who had been evaluated by the same method 8 years before. Results: We observed the lowest L/N relation in patients with active disease, especially those with polyarticular course. A statistical con-elation was also observed with the acute-phase reactants (ESR and CRP, p < 0.05). The majority of patients who had presented a low L/N relation at the first evaluation (8 years before) had a worse outcome. Conclusion: The measure of L/N relation from peripheral blood could be used as an auxiliary tool in the assessment of the activity and outcome of JIA patients, especially at disease onset. en
dc.format.extent 103-107
dc.language.iso eng
dc.publisher Hogrefe & Huber Publishers
dc.relation.ispartof Journal Of Investigational Allergology And Clinical Immunology
dc.rights Acesso restrito
dc.subject juvenile idiopathic arthritis en
dc.subject juvenile rheumatoid arthritis en
dc.subject neutrophils en
dc.subject disease activity en
dc.subject outcome en
dc.title Low density neutrophils in patients with juvenile idiopathic arthritis en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Pediat Rheumatol Unit, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Rheumatol Unit, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Pediat Rheumatol Unit, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Rheumatol Unit, Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000185522500005



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