Low density neutrophils in patients with juvenile idiopathic arthritis

Low density neutrophils in patients with juvenile idiopathic arthritis

Author Ronchezel, M. V. Google Scholar
Hacbarth, E. T. Google Scholar
Len, Claudio Arnaldo Autor UNIFESP Google Scholar
Terreri, Maria Teresa Autor UNIFESP Google Scholar
Andrade, LEC Autor UNIFESP Google Scholar
Hilário, Maria Odete Esteves Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives: (1) To study the correlation among conventional clinical and laboratory parameters and the relation between the number of lymphocytes and neutrophils (L/N) in cell suspensions from peripheral blood of patients with juvenile idiopathic arthritis (JIA). (2) To evaluate the L/N relation of RA patients after an 8 year follow-up period. Methods: Fifty-one JIA patients (25 female, disease course: 19 systemic, 15 polyarticular, 17 pauciarticular) were enrolled in the study. To measure the L/N relation, we used Boyum's method: The leucocyte separation was done by centrifugation of peripheral blood on Ficoll-Hypaque (FH) gradient, and the number of lymphocytes, monocytes, and neutrophils in 500 cells was determined. The following clinical and laboratory parameters were evaluated: disease activity, number of active and limited joints, functional capacity, erythrocyte sedimentation rate (ESR), and C reactive protein (CRP). Twenty-four healthy children were used as controls. We also studied 13/51 patients from our Pediatric Rheumatology Unit who had been evaluated by the same method 8 years before. Results: We observed the lowest L/N relation in patients with active disease, especially those with polyarticular course. A statistical con-elation was also observed with the acute-phase reactants (ESR and CRP, p < 0.05). The majority of patients who had presented a low L/N relation at the first evaluation (8 years before) had a worse outcome. Conclusion: The measure of L/N relation from peripheral blood could be used as an auxiliary tool in the assessment of the activity and outcome of JIA patients, especially at disease onset.
Keywords juvenile idiopathic arthritis
juvenile rheumatoid arthritis
neutrophils
disease activity
outcome
Language English
Date 2003-01-01
Published in Journal Of Investigational Allergology And Clinical Immunology. Gottingen: Hogrefe & Huber Publishers, v. 13, n. 2, p. 103-107, 2003.
ISSN 1018-9068 (Sherpa/Romeo, impact factor)
Publisher Hogrefe & Huber Publishers
Extent 103-107
Access rights Closed access
Type Article
Web of Science ID WOS:000185522500005
URI http://repositorio.unifesp.br/11600/44463

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