Profile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazil

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dc.contributor.author Bueno de Sa, A. [UNIFESP]
dc.contributor.author Faria Camilo Araujo, R. [UNIFESP]
dc.contributor.author Cavalheiro, S. [UNIFESP]
dc.contributor.author Carvalho Mallozi, M. [UNIFESP]
dc.contributor.author Sole, D. [UNIFESP]
dc.date.accessioned 2018-06-15T18:02:41Z
dc.date.available 2018-06-15T18:02:41Z
dc.date.issued 2013-01-01
dc.identifier http://www.jiaci.org/summary/vol23-issue1-num949
dc.identifier.citation Journal Of Investigational Allergology And Clinical Immunology. Barcelona: Esmon Publicidad S A, v. 23, n. 1, p. 43-49, 2013.
dc.identifier.issn 1018-9068
dc.identifier.uri http://repositorio.unifesp.br/11600/44459
dc.description.abstract Background: Latex allergy is an important cause of occupational allergy. In many countries the prevalence of latex allergy is still high and the profile of latex sensitization is unknown.Objectives: To evaluate the frequency of sensitization and allergy to latex in children and adolescents with myelomeningocele and to identify associated risk factors.Methods: The study included 55 children and adolescents with myelomeningocele followed at a specialized center. In addition to a standard questionnaire and skin prick tests (SPTs) to aeroallergens and total latex, the patients underwent determination of total and specific serum IgE to latex and recombinant allergens.Results: We observed a prevalence of 25% for latex sensitization and of 20% for latex allergy. Twenty-four patients (43.6%) were atopic and the average age for the first reaction to latex was 44.5 months. Cutaneous reactions were the most frequently reported reactions (72.7%). Specific immunoglobulin (Ig) E to rHey b 1, rHev b 3, rHev b 5, rHey b 6.1, and rHev b 6.2 was detected in over 50% of patients allergic,to latex. Multivariate analysis showed current asthma, atopy, and having undergone 4 or more operations to be risk factors for latex sensitization.Conclusions: Our study documented a high prevalence of sensitization and allergy to latex in patients with myelomeningocele. Specific IgE to rHey b 1, rHey b 3, rHev b 5, rHey b 6.1, and rHey b 6.2 was detected in over 50% of children and adolescents with myelomeningocele who are allergic to latex. A history of current asthma, atopy, and having undergone 4 or more operations were independent risk factors for latex allergy. en
dc.format.extent 43-49
dc.language.iso eng
dc.publisher Esmon Publicidad S A
dc.relation.ispartof Journal Of Investigational Allergology And Clinical Immunology
dc.rights Acesso aberto
dc.subject Allergy en
dc.subject Latex en
dc.subject Myelomeningocele en
dc.subject Recombinant allergens en
dc.subject Brazil en
dc.title Profile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazil en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Dept Pediat, Div Allergy & Clin Immunol & Rheumatol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Neurol, Div Neurosurg, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pediat, Div Allergy & Clin Immunol & Rheumatol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Neurol, Div Neurosurg, Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000316536500007



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