Profile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazil

Profile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazil

Author Bueno de Sa, A. Autor UNIFESP Google Scholar
Faria Camilo Araujo, R. Autor UNIFESP Google Scholar
Cavalheiro, S. Autor UNIFESP Google Scholar
Carvalho Mallozi, M. Autor UNIFESP Google Scholar
Sole, D. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Latex allergy is an important cause of occupational allergy. In many countries the prevalence of latex allergy is still high and the profile of latex sensitization is unknown.Objectives: To evaluate the frequency of sensitization and allergy to latex in children and adolescents with myelomeningocele and to identify associated risk factors.Methods: The study included 55 children and adolescents with myelomeningocele followed at a specialized center. In addition to a standard questionnaire and skin prick tests (SPTs) to aeroallergens and total latex, the patients underwent determination of total and specific serum IgE to latex and recombinant allergens.Results: We observed a prevalence of 25% for latex sensitization and of 20% for latex allergy. Twenty-four patients (43.6%) were atopic and the average age for the first reaction to latex was 44.5 months. Cutaneous reactions were the most frequently reported reactions (72.7%). Specific immunoglobulin (Ig) E to rHey b 1, rHev b 3, rHev b 5, rHey b 6.1, and rHev b 6.2 was detected in over 50% of patients allergic,to latex. Multivariate analysis showed current asthma, atopy, and having undergone 4 or more operations to be risk factors for latex sensitization.Conclusions: Our study documented a high prevalence of sensitization and allergy to latex in patients with myelomeningocele. Specific IgE to rHey b 1, rHey b 3, rHev b 5, rHey b 6.1, and rHey b 6.2 was detected in over 50% of children and adolescents with myelomeningocele who are allergic to latex. A history of current asthma, atopy, and having undergone 4 or more operations were independent risk factors for latex allergy.
Keywords Allergy
Latex
Myelomeningocele
Recombinant allergens
Brazil
Language English
Date 2013-01-01
Published in Journal Of Investigational Allergology And Clinical Immunology. Barcelona: Esmon Publicidad S A, v. 23, n. 1, p. 43-49, 2013.
ISSN 1018-9068 (Sherpa/Romeo, impact factor)
Publisher Esmon Publicidad S A
Extent 43-49
Origin http://www.jiaci.org/summary/vol23-issue1-num949
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316536500007
URI http://repositorio.unifesp.br/11600/44459

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