Methotrexate in the treatment of corticodependent asthmatic children

Methotrexate in the treatment of corticodependent asthmatic children

Author Sole, D. Google Scholar
CostaCarvalho, B. T. Google Scholar
Soares, FJP Google Scholar
Rullo, V. V. Google Scholar
Naspitz, C. K. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Methotrexate has been used as an anti-inflammatory agent in chronic asthma. We evaluated the action of methotrexate in eight corticodependent severely asthmatic children (more than 10 mg of prednisone per day for at least one year). The patients (3 males and 5 females; aged 8 to 14 years) received a single weekly dose of 0.6 mg/kg methotrexate (maximum 25 mg) and folio acid (15 mg/day for 5 days in the week). The children were examined and had their pulmonar function test evaluated weekly. As the study progressed, the dose of prednisone was reduced and maintained till the next evaluation if the patient's symptoms were under control. After the 3rd month of treatment we observed a significant reduction in the dose of prednisone and maintenance of the spirometric parameters. At the end of the trial, in 4 patients it was possible to reduce the basal prednisone dose 56% or more. In the remaining 4, one did not show any benefit and in the other 3, it was possible to obtain an average reduction of 40% of the basal prednisone dose. The total mean reduction was 55.9%. This oral corticoid reduction was not associated with clinical or pulmonary function deterioration, except in one patient The patients were submitted to white blood cell count, hepatic transaminases, urine tests and other determinations at least once a month. There were no changes in biochemical tests. The side-effects were nausea, vomiting and abdominal pain. In conclusion, methotrexate given to severely corticodependent asthmatic children permitted a reduction in the daily intake of prednisone, reducing the severe side-effects of chronic corticotherapy.
Keywords severe asthma
corticosteroid sparing
Language English
Date 1996-03-01
Published in Journal Of Investigational Allergology & Clinical Immunology. Barcelona: J R Prous Sa, v. 6, n. 2, p. 126-130, 1996.
ISSN 1018-9068 (Sherpa/Romeo, impact factor)
Publisher J R Prous Sa
Extent 126-130
Access rights Closed access
Type Article
Web of Science ID WOS:A1996UL26600009

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