Clinical and laboratory characteristics of acute hepatitis C in patients with end-stage renal disease on hemodialysis

Clinical and laboratory characteristics of acute hepatitis C in patients with end-stage renal disease on hemodialysis

Author Lemos, Lara Barros Autor UNIFESP Google Scholar
Perez, Renata de Mello Autor UNIFESP Google Scholar
Matos, Carla Adriana Loureiro de Autor UNIFESP Google Scholar
Silva, Ivonete S. Autor UNIFESP Google Scholar
Silva, Antonio Eduardo Benedito Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Patients with end-stage renal disease (ESRD) undergoing hemodialysis are a risk group for hepatitis C virus (HCV) infection. The characteristics of acute hepatitis C infection in this population are not well known.Goals: To evaluate the clinical and laboratory characteristics of acute hepatitis C in ESRD patients treated with hemodialysis.Study: ESRD patients on hemodialysis with acute hepatitis C, characterized by elevated alanine aminotransferase (ALT) followed by anti-HCV seroconversion were studied.Results: Thirty-six patients (58% females, 44 +/- 12 y), with a mean time on hemodialysis of 2 years, were included. Only 2 (6%) patients had jaundice. ALT elevation was observed in all patients. Median peak ALT was 4.7 x upper limit of normal. The median interval between ALT elevation and anti-HCV seroconversion was I month (0 to 8). None of the patients with detectable HCV-RNA showed spontaneous clearance of viremia within 12 weeks of follow-up. Three (8%) patients presented ALT elevation followed by anti-HCV seroconversion with undetectable HCV-RNA.Conclusions: Acute hepatitis C is frequently asymptomatic in ESRD patients on hemodialysis and should be suspected in all patients presenting elevated ALT. Determination of HCV-RNA is important for the confirmation of infection. Anti-HCV seroconversion seems to occur early and spontaneous clearance of HCV-RNA is uncommon.
Keywords acute hepatitis C
anti-HCV
HCR-RNA
end-stage renal disease
hemodialysis
Language English
Date 2008-02-01
Published in Journal Of Clinical Gastroenterology. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 2, p. 208-211, 2008.
ISSN 0192-0790 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 208-211
Origin http://dx.doi.org/10.1097/MCG.0b013e31802dc57f
Access rights Closed access
Type Article
Web of Science ID WOS:000252862400018
URI http://repositorio.unifesp.br/11600/44264

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