Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom

Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom

Alternative title Caracterización Molecular, Electrofisiológica y Efecto Anticonceptivo del Veneno de Latrodectus Chilena
Author Gomez, Patricia Navarrete Autor UNIFESP Google Scholar
Ormeno, David Google Scholar
Miranda, Antonio Autor UNIFESP Google Scholar
Gutierrez, Raul Sanchez Google Scholar
Romero Mejia, Fernando Gonzalo Autor UNIFESP Google Scholar
Rivera, Jorge Parodi Google Scholar
Institution Univ La Frontera
Universidade Federal de São Paulo (UNIFESP)
Abstract Since the 1970s, There have been studies of the venom of Latrodectus sp. spiders, in particular the latrotoxin (LTX) of Latrodectus mactans. Many of the studies were aimed at understanding the action of the venom on the muscular system. Now accepted that LTX is able to generate a calcium-permeable membrane pore and modulate the release of synaptic vesicles that activate a receptor and induce cellular changes. Interestingly, when work began with venom obtained from the Latrodectus sp present in Chile, it generated clinical indications similar to the bite of this spider in another country, with some differences in intensity. The purpose of the first studies was to understand the systemic mechanisms of this venom, and other active compounds were studied for biological interest. It was found that these molecules are capable of causing systemic effects such as changes in muscle contraction; of generating vascular relaxation and synaptic and cellular modulation; and of altering potassium conductance channels. Based on this evidence, we suggested biotechnological applications to characterize low molecular-weight compounds obtained from the Chilean Latrodectus venom and exploring the effects on the electrophysiology in oocytes and neurons, and the contraceptive effect on spermatozoa.
Keywords Latrodectus venom
Oocytes
Neurons
Spermatozoa
Contraceptive
Language English
Sponsor FONDEF-CONICYT Chile
Universidad de la Frontera
CONICYT
Grant number FONDEF-CONICYT Chile: DO5I10416
Date 2011-01-01
Published in International Journal Of Morphology. Temuco: Soc Chilena Anatomia, v. 29, n. 3, p. 733-741, 2011.
ISSN 0717-9502 (Sherpa/Romeo, impact factor)
Publisher Soc Chilena Anatomia
Extent 733-741
Origin http://dx.doi.org/10.4067/S0717-95022011000300012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000299647600012
SciELO ID S0717-95022011000300012 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/44081

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