Interleukin-6 polymorphisms and the risk of cervical cancer

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dc.contributor.author Souza, NCN de
dc.contributor.author Brenna, SMF
dc.contributor.author Campos, F.
dc.contributor.author Syrjanen, K. J.
dc.contributor.author Baracat, Edmund Chada [UNIFESP]
dc.contributor.author Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.date.accessioned 2018-06-15T17:44:21Z
dc.date.available 2018-06-15T17:44:21Z
dc.date.issued 2006-05-01
dc.identifier http://doi.org/10.1111/j.1525-1438.2006.00521.x
dc.identifier.citation International Journal Of Gynecological Cancer. Oxford: Blackwell Publishing, v. 16, n. 3, p. 1278-1282, 2006.
dc.identifier.issn 1048-891X
dc.identifier.uri http://repositorio.unifesp.br/11600/44044
dc.description.abstract Recent data implicate that cytokine gene polymorphisms are important in pathogenesis of various neoplastic and nonneoplastic human diseases, and it was recently suggested that polymorphisms in interleukin (IL)-6 might increase the risk of gynecological malignancies, including cervical carcinomas. The aim of this case-control study is to compare the IL-6 polymorphisms in cervical cancer patients and healthy controls and to assess whether any of these polymorphisms would increase the risk of developing cervical cancer. The material in this case-control study consists of 56 patients with cervical carcinoma and 253 population-based control subjects, all ethnic Brazilian women. Control subjects were cancer-free women, following a negative cervical cytology and colposcopy. IL-6 genotyping was performed using a polymerase chain reaction-based restriction fragment length polymorphism. Distribution of the GG, GC, and CC genotypes in cases and controls was significantly different (P = 0.033). Compared with the GG genotype as reference, the adjusted odds ratio for the combined GC and CC genotypes in cancer patients was 1.90 (95% confidence interval, 1.1-3.4). These data suggest that women carrying at least one C genotype in their IL-6 promoter region (-174G -> C) are at higher risk of developing cervical cancer. en
dc.format.extent 1278-1282
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.relation.ispartof International Journal Of Gynecological Cancer
dc.rights Acesso restrito
dc.subject cervical cancer en
dc.subject IL-6 en
dc.subject polymorphisms en
dc.subject risk factor en
dc.title Interleukin-6 polymorphisms and the risk of cervical cancer en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Leonor Mendes Barros Matern Hosp
dc.contributor.institution Turku Univ
dc.description.affiliation Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliation Leonor Mendes Barros Matern Hosp, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliation Turku Univ, Cent Hosp, Dept Oncol, Turku, Finland
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.identifier.doi 10.1111/j.1525-1438.2006.00521.x
dc.description.source Web of Science
dc.identifier.wos WOS:000238255300049



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