5-Fluorouracil superficial peel for multiple actinic keratoses

5-Fluorouracil superficial peel for multiple actinic keratoses

Author Bagatin, Edileia Autor UNIFESP Google Scholar
Teixeira, Solange Pistori Autor UNIFESP Google Scholar
Hassun, Karime Marques Autor UNIFESP Google Scholar
Pereira, Taise Google Scholar
Michalany, Nilceo Schwery Autor UNIFESP Google Scholar
Talarico, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract BackgroundChronically photodamaged skin usually presents with multiple, widespread, actinic keratoses (AKs), and treatment of the entire affected area is recommended.MethodsWe report our experience with a combination of Jessner's solution or 70% glycolic acid (GA) with 5% 5-fluorouracil (5-FU) solution for superficial pulse peeling used in the treatment of widespread AKs in 31 patients. Pulse peelings were performed at biweekly intervals. The endpoint for treatment was complete or maximum clearance of the lesions at clinical evaluation. Pre- and post-skin biopsy and histopathologic examination were performed in three patients for the purpose of demonstrating the pulse peel effects.ResultsAll patients achieved a satisfactory result, including the complete regression, or at least 80% clearing, of AK lesions and an overall improvement of photodamaged skin.ConclusionWe consider this superficial 5-FU pulse peel to be a safe, well-tolerated, very effective, and highly inexpensive therapeutic option for the treatment of multiple, diffuse AKs. Its benefit/cost ratio will be of interest to public health services, mainly in developing countries.
Language English
Date 2009-08-01
Published in International Journal Of Dermatology. Malden: Wiley-blackwell Publishing, Inc, v. 48, n. 8, p. 902-907, 2009.
ISSN 0011-9059 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 902-907
Origin http://doi.org/10.1111/j.1365-4632.2009.04106.x
Access rights Closed access
Type Article
Web of Science ID WOS:000268175400021
URI http://repositorio.unifesp.br/11600/44039

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