Gastroduodenal lesions in children with juvenile rheumatoid arthritis

Gastroduodenal lesions in children with juvenile rheumatoid arthritis

Author Len, Claudio Arnaldo Autor UNIFESP Google Scholar
Hilário, Maria Odete Esteves Autor UNIFESP Google Scholar
Kawakami, Elisabete Autor UNIFESP Google Scholar
Terreri, Maria Teresa Ramos Ascensão Autor UNIFESP Google Scholar
Becker, D. J. Google Scholar
Goldenberg, José Autor UNIFESP Google Scholar
Fagundes Neto, Ulysses Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract BACKGROUND/AIMS: There are few studies about gastrointestinal abnormalities in patients with juvenile rheumatoid arthritis - probably due to the fact that this association is not frequently recognized. The aim of our study was to observe the prevalence of endoscopic gastroduodenal lesions in these patients.METHODOLOGY: Fourteen patients with juvenile rheumatoid arthritis, all of them using non-steroidal anti-inflammatory drugs associated or not with methotrexate, were assessed clinically and by endoscopy. Gastric antrum biopsy and Helicobacter pylori search were also performed.RESULTS: The mean age of the patients was 10.6 years (7 boys). Abdominal pain was observed in 27% of them. Macroscopic endoscopic lesions were found in 43% and infection by Helicobacter pylori in 57%. The correlation between anemia and endoscopic abnormalities was statistically significant (p<0.05).CONCLUSIONS: Our data show that patients with juvenile rheumatoid arthritis have considerable susceptibility to gastroduodenal lesions, especially if they are using any drug association and present anemia.
Keywords juvenile rheumatoid arthritis
non-steroidal anti-inflammatory drugs
Language English
Date 1999-03-01
Published in Hepato-gastroenterology. Athens: H G E Update Medical Publ Ltd., v. 46, n. 26, p. 991-996, 1999.
ISSN 0172-6390 (Sherpa/Romeo, impact factor)
Publisher H G E Update Medical Publ Ltd.
Extent 991-996
Access rights Closed access
Type Article
Web of Science ID WOS:000080360400067

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