Gastrin levels in patients with colorectal cancer

Gastrin levels in patients with colorectal cancer

Author Blum, Vinicius Fontanesi Autor UNIFESP Google Scholar
Barone, Boris Autor UNIFESP Google Scholar
Mattos, D. Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background/Aims: In view of previous studies showing gastrin 's trophic effects on tumor growth, the authors decided to investigate the relationship between fasting serum gastrin levels and the presence of colorectal carcinoma.Methodology: Fifty-eight patients were studied: 19 controls who were blood bank donors, 19 patients with colorectal neoplasms, Dukes' Stage B or C, and 20 patients with advanced colorectal neoplasms (Dukes Stage D). Pre-surgical and post-surgical serum gastrin bevels were compared in patients with colorectal neoplasms (Dukes' Stage B or C).Results: The mean serum gastrin level was 32.3pg/ml for the control group, 52.1 pg/ml for the second group and 49.5pg/ml for the third group. There were no differences between, patients before and after surgery.Conclusion: These results do not confirm the hypothesis that gastrin levels are elevated in colorectal cancer patients.
Keywords colorectal cancer
serum gastrin
tumor growth
Language English
Date 1997-07-01
Published in Hepato-gastroenterology. Athens: H G E Update Medical Publ Ltd., v. 44, n. 16, p. 1082-1084, 1997.
ISSN 0172-6390 (Sherpa/Romeo, impact factor)
Publisher H G E Update Medical Publ Ltd.
Extent 1082-1084
Access rights Closed access
Type Article
Web of Science ID WOS:A1997XP15900026

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