Reduction of the activity of ribosomal genes with age in Down's syndrome

Reduction of the activity of ribosomal genes with age in Down's syndrome

Author Borsatto-Galera, Bianca Autor UNIFESP Google Scholar
Smith, MDC Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The hypothesis of the coparticipation of ribosomal genes in controlling the differential expression of genes with age is analyzed in Down's syndrome. The activity of ribosomal genes was tested cytogenetically by Ag-stained nucleolar organizer regions and by satellite association in lymphocytes from 40 patients with Down's syndrome. Twenty patients were between 0 and 25 years old, and the others were between 29 and 48 years old. Our results showed a significant decrease with regard to total Ag staining and in relation to each chromosome pair in the older Down's syndrome group as compared with the younger group. The total number of associated chromosomes and the number of associations of each chromosome pair were both significantly lower. The results show a decreased activity of ribosomal genes with age. This reduction may originate from changes in regulation and expression of these genes that might result in differing cell translation ability.
Keywords Down's syndrome
nucleolus organizer regions
ribosomal genes
transcriptional activity
Language English
Date 1996-05-01
Published in Gerontology. Basel: Karger, v. 42, n. 3, p. 147-154, 1996.
ISSN 0304-324X (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 147-154
Access rights Closed access
Type Editorial
Web of Science ID WOS:A1996UR56100003

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