Bovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animals

Bovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animals

Author Lindsey, Charles Julian Autor UNIFESP Google Scholar
Almeida, Marcos Eduardo de Autor UNIFESP Google Scholar
Vicari, C. F. Autor UNIFESP Google Scholar
Carvalho, C. Google Scholar
Yaguiu, A. Google Scholar
Freitas, A. C. Google Scholar
Becak, W. Google Scholar
Stocco, Rita de Cassia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Butantan
Universidade Federal de Pernambuco (UFPE)
Abstract Papillomavirus infection in bovines is associated with cutaneous papillomatosis on the hide, udders and other epithelial tissues, as well as in oral respiratory, alimentary and urinary tract mucosa. Bovine papillomavirus (BPV) is also considered the etiological agent of esophageal tumors and the malignant bladder tumors that characterize the clinical condition associated with chronic enzootic hematuria. After infective viral DNA was found in cattle blood and BPV1, 2 and 4 DNA in cattle reproductive and embryonic tissues, we looked for and found BPV DNA in blood, milk, urine, seminal fluid, and spermatozoa of BPV-infected animals. Peripheral blood lymphocyte cultures from BPV-infected animals had high rates of chromosome aberrations, including radial rearrangements that signal oncogenic potential and viral interaction with telomeric regions. The finding of BPV DNA in body fluids and tissues other than the epithelium demonstrates co-infection of other tissues or cell types by papillomavirus and shows the potential role of lymphocytes, seminal fluid and spermatozoa in BPV transmission. Our findings reinforce a peremptory need for prophylactic and therapeutic instruments to curtail this disease in bovine livestock.
Keywords Bovine papillomavirus
Blood
Milk
Urine
Semen
Spermatozoa
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2009-01-01
Published in Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 8, n. 1, p. 310-318, 2009.
ISSN 1676-5680 (Sherpa/Romeo, impact factor)
Publisher Funpec-editora
Extent 310-318
Origin http://dx.doi.org/10.4238/vol8-1gmr573
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000265578600031
URI http://repositorio.unifesp.br/11600/43722

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