Differential gene expression assessed by cDNA microarray analysis in breast cancer tissue under tamoxifen treatment

Differential gene expression assessed by cDNA microarray analysis in breast cancer tissue under tamoxifen treatment

Author Wolgien, Maria Del Carmen Garcia Molina Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Villanova, Fabiola Elizabeth Autor UNIFESP Google Scholar
Otsuka, Audrey Yumi Autor UNIFESP Google Scholar
Borra, Ricardo Carneiro Autor UNIFESP Google Scholar
Reis, LFL Google Scholar
Carvalho, A. E. Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Gebrim, Luiz Henrique Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ludwig Inst Canc Res
Abstract Our purpose was to identify tamoxifen (TAM) responsive genes after 30 days of TAM treatment in tumor tissues obtained from women with breast cancer using microarray expression analysis. In our study, we identified 12 candidates to be considered as tamoxifen-modulated genes. Among them, we selected two candidates the TEGT BI-1 (testis enhanced gene transcript Bax Inhibitor-1) and the CD63 gene in order to further confirm their differential expression under tamoxifen effects. We observed that both were down-regulated in tumor tissues of patients during TAM treatment. TEGT is able to inhibit the expression of Bax, which is known to promote apoptosis. On the other hand, CD63 encodes a cell membrane protein and it seems to be involved in mechanisms of platelet activation. cell adhesion and cell motility. We therefore hypothesize that TAM would be able to modulate tumor growth by down-regulating genes involved in mechanisms such as cell cycle control, tumor invasion and metastasis.
Keywords cDNA microarray analysis
breast cancer
Language English
Date 2005-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 26, n. 5, p. 501-504, 2005.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 501-504
Origin http://www.irog.net/download/?magazine=88
Access rights Closed access
Type Article
Web of Science ID WOS:000233029200006
URI http://repositorio.unifesp.br/11600/43592

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