Granular cell dispersion and bilamination: two distinct and bilamination, histopathological patterns in epileptic hippocampi?

Granular cell dispersion and bilamination: two distinct and bilamination, histopathological patterns in epileptic hippocampi?

Author Silva, Alexandre Valotta da Autor UNIFESP Google Scholar
Houzel, Jean-Christophe Google Scholar
Croaro, Ingrid Autor UNIFESP Google Scholar
Stávale, João Norberto Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Cytoarchitectural modifications of the dentate gyrus are among the most obvious abnormalities observed in the hippocampal sclerosis associated with refractory epilepsy. Here, we examined the morphological changes of granular cells (dispersion, bilamination and cell loss) in sclerotic hippocampi from nine TLE patients, comparing abnormal and preserved areas. A total of 2 577 granular cells were analyzed with respect to four different histopathological patterns: areas with bilamination (n = 936), areas with dispersion (n = 905), areas with neuronal loss (n = 279), and preserved areas (n = 457). Quantitative parameters included somatic perimeter (P), area (A) and form factor (ff).Although different patterns were often observed in the same patient, highly significant differences were observed (p < 0.0001) when patterns were compared to one another. Since granular cell dispersion and bilamination have different morphological aspects in sclerotic hippocampi from TLE patients, we suggest that these patterns should be considered separately. Future studies are needed to determine the frequency with which these patterns occur in the general population and whether each one can interfere with seizure susceptibility.
Keywords hippocampal sclerosis
refractory epilepsy
immunocytochemistry
morphometry
temporal lobe
Language English
Date 2007-12-01
Published in Epileptic Disorders. Montrouge: John Libbey Eurotext Ltd, v. 9, n. 4, p. 438-442, 2007.
ISSN 1294-9361 (Sherpa/Romeo, impact factor)
Publisher John Libbey Eurotext Ltd
Extent 438-442
Origin http://www.jle.com/en/revues/epd/e-docs/granular_cell_dispersion_and_bilamination_two_distinct_histopathological_patterns_in_epileptic_hippocampi__276425/article.phtml
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000252669900007
URI http://repositorio.unifesp.br/11600/43571

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