Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy

Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy

Author Carvalho, R. D. Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin.Methods: Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling.Results: From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4-5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1-3 and 5 and longer after discharge duration in stages 1-4 was observed in the Proechimys group compared with the Wistar group. The number of wet-dog shakes also was reduced in the Proechimys group during the kindling process.Conclusions: These findings suggest natural endogenous inhibitory mechanisms in this animal species.
Keywords kindling
epilepsy
Proechimys
rats
Language English
Date 2003-02-01
Published in Epilepsia. Hoboken: Wiley-blackwell, v. 44, n. 2, p. 165-170, 2003.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 165-170
Origin https://dx.doi.org/10.1046/j.1528-1157.2003.32202.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000180917100005
URI http://repositorio.unifesp.br/11600/43552

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