Conducting cost-effectiveness analyses of type 2 diabetes in low- and middle-income countries: can locally generated observational study data overcome methodological limitations?

Conducting cost-effectiveness analyses of type 2 diabetes in low- and middle-income countries: can locally generated observational study data overcome methodological limitations?

Author Baik, SeiHyun Google Scholar
Chacra, Antonio Roberto Autor UNIFESP Google Scholar
Li Yuxiu Google Scholar
White, Jeremy Google Scholar
Gueler, Serdar Google Scholar
Latif, Zafar A. Google Scholar
Institution Novo Nordisk Reg Int Operat AS
Korea Univ Guro Hosp
Universidade Federal de São Paulo (UNIFESP)
Beijing Union Med Coll Hosp
Ankara Numune Training & Res Hosp
Bangladesh Inst Res & Rehabil Diabet Endocrine &
Abstract In low- and middle-income countries, the high personal and economic burden of type 2 diabetes is further compounded by inadequate resources for diabetes care when compared with high-income countries. Health technology assessments (HTAs) aim to inform policy decision makers in their efforts to achieve more effective allocation of resources by providing evidence-based input on new technologies. Within the hierarchy of evidence, randomized controlled trials (RCTs) remain the 'gold standard' used to inform HTAs, but are limited by poor external validity (ie, generalizability to real-world populations). Unlike RCTs, observational studies are able to enrol broader patient populations, but their design renders such studies vulnerable to confounding factors and selection bias. However, it is increasingly recognized that observational studies can complement RCTs by supporting and extending efficacy findings from RCTs to real-world clinical practice, particularly across geographical populations. They can also provide locally relevant baseline and disease natural history data to populate health economic models. Thus, observational data are likely to be of considerable informative value to policy makers in developing countries reaching decisions on diabetes care within art environment of scarce resources. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Keywords Type 2 diabetes
Health economic models
Observational studies
Cost-effectiveness analyses
Language English
Sponsor Novo Nordisk, MSD
Sanofi-Aventis
Date 2010-05-01
Published in Diabetes Research And Clinical Practice. Clare: Elsevier Ireland Ltd, v. 88, p. S17-S22, 2010.
ISSN 0168-8227 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent S17-S22
Origin http://dx.doi.org/10.1016/S0168-8227(10)70004-8
Access rights Closed access
Type Article
Web of Science ID WOS:000278194900004
URI http://repositorio.unifesp.br/11600/43483

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