Dietary riboflavin restriction and chronic hemin administration does not alter brain function in rats: The importance of vitamin homeostasis in the brain

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dc.contributor.author DalPai, Janise [UNIFESP]
dc.contributor.author Borges, Andrea Aurélio [UNIFESP]
dc.contributor.author Grassl, Christian [UNIFESP]
dc.contributor.author Favero Filho, Luiz Antonio [UNIFESP]
dc.contributor.author Xavier, Gilberto Fernando [UNIFESP]
dc.contributor.author Junqueira, Virginia Berlanga Campos [UNIFESP]
dc.contributor.author Lopes, Antonio Carlos [UNIFESP]
dc.contributor.author Coimbra, Cicero Galli [UNIFESP]
dc.contributor.author Sinigaglia-Coimbra, Rita [UNIFESP]
dc.date.accessioned 2018-06-15T17:05:16Z
dc.date.available 2018-06-15T17:05:16Z
dc.date.issued 2007-11-01
dc.identifier http://ctnr.newcenturyhealthpublishers.com/about/pdf/ctnrv5p149_156.pdf
dc.identifier.citation Current Topics In Nutraceutical Research. Coppell: New Century Health Publishers, Llc, v. 5, n. 4, p. 149-155, 2007.
dc.identifier.issn 1540-7535
dc.identifier.uri http://repositorio.unifesp.br/11600/43477
dc.description.abstract Vitamin B2 deficiency associated with normal dietary intake has been reported inpatients with Parkinson disease (PD), suggesting impaired absorption of this micronutrient. Elevated red meat consumption was thought to contribute as a triggering factor, as the catabolism of hemin (a neurotoxic substance) requires vitamin B2 (Coimbra &Junqueira, 2003). This study tested this hypothesis by verifying the effects of dietary riboflavin restriction associated with hemin administration on rat brain. After 8 months of riboflavin restriction, riboflavin deficiency with or without oral administration of hemin (assessed by erythrocyte glutathion ereductase activity) did not impair motor function or spatial learning; neither altered the volume of substantia nigra or brain concentrations of total glutathione. Partial dietary restriction of riboflavin may failed to induce oxidative stress in the rat brain and dopaminergic degeneration in the rat substantia nigra as suggested to occur in humans by Coimbra & Junqueita, (2003), possibly due to an intact mechanism of nutritional privilege that preserves riboflavin content in the normal rat brain during deficiency states. Contrastingly, polymorphic enzymes or receptors involved in the human cellular uptake of ribofiavin may conceivably impair the transport of this micronutrient not only through the intestinal wall and renal tubules, but also in the brain of PD patients, there by annulling the nutritional privilege of the nervous system. en
dc.format.extent 149-155
dc.language.iso eng
dc.publisher New Century Health Publishers, Llc
dc.relation.ispartof Current Topics In Nutraceutical Research
dc.rights Acesso aberto
dc.subject FAD en
dc.subject glutathione en
dc.subject hemin en
dc.subject Parkinson's disease en
dc.subject riboflavin en
dc.subject substantia nigra en
dc.title Dietary riboflavin restriction and chronic hemin administration does not alter brain function in rats: The importance of vitamin homeostasis in the brain en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Lab Clin & Expt Physiopathol, Dept Med, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Morphol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Physiol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, COLSAN, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Ctr Electron Microscopy, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Lab Clin & Expt Physiopathol, Dept Med, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Morphol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Physiol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, COLSAN, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Ctr Electron Microscopy, BR-04039032 Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000255670800002



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