Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia

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dc.contributor.author Levin, Raquel [UNIFESP]
dc.contributor.author Almeida, Valeria [UNIFESP]
dc.contributor.author Peres, Fernanda Fiel [UNIFESP]
dc.contributor.author Calzavara, Mariana Bendlin [UNIFESP]
dc.contributor.author Silva, Neide Derci da [UNIFESP]
dc.contributor.author Suiama, Mayra Akimi [UNIFESP]
dc.contributor.author Niigaki, Suzy Tamie [UNIFESP]
dc.contributor.author Zuardi, Antonio Waldo [UNIFESP]
dc.contributor.author Hallak, Jaime Eduardo Cecilio
dc.contributor.author Crippa, Jose Alexandre de Souza
dc.contributor.author Abilio, Vanessa Costhek [UNIFESP]
dc.date.accessioned 2018-06-15T17:05:15Z
dc.date.available 2018-06-15T17:05:15Z
dc.date.issued 2012-11-01
dc.identifier http://dx.doi.org/10.2174/138161212802884735
dc.identifier.citation Current Pharmaceutical Design. Sharjah: Bentham Science Publ Ltd, v. 18, n. 32, p. 4960-4965, 2012.
dc.identifier.issn 1381-6128
dc.identifier.uri http://repositorio.unifesp.br/11600/43467
dc.description.abstract Objectives: Clinical and neurobiological findings suggest that cannabinoids and their receptors are implicated in schizophrenia. Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa plant, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that spontaneously hypertensive rats (SHR) present a deficit in contextual fear conditioning (CFC) that is specifically ameliorated by antipsychotics and aggravated by proschizophrenia manipulations. These results led us to suggest that the CFC deficit presented by SHR could be used as a model to study emotional processing impairment in schizophrenia. The aim of this study is to evaluate the effects of CBD and rimonabant (CB1 receptor antagonist) on the contextual fear conditioning in SHR and Wistar rats (WR). Methods: Rats were submitted to CFC task after treatment with different doses of CBD (experiment 1) and rimonabant (experiment 2). Results: In experiment 1, SHR showed a decreased freezing response when compared to WR that was attenuated by 1 mg/kg CBD. Moreover, all CBD-treated WR presented a decreased freezing response when compared to control rats. In experiment 2, SHR showed a decreased freezing response when compared to WR that was attenuated by 3 mg/kg rimonabant. Discussion: Our results suggest a potential therapeutical effect of CBD and rimonabant to treat the emotional processing impairment presented in schizophrenia. In addition, our results reinforce the anxiolytic profile of CBD. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 4960-4965
dc.language.iso eng
dc.publisher Bentham Science Publ Ltd
dc.relation.ispartof Current Pharmaceutical Design
dc.rights Acesso restrito
dc.subject Schizophrenia en
dc.subject cannabidiol en
dc.subject rimonabant en
dc.subject contextual fear conditioning en
dc.subject SHR en
dc.title Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution CNPq
dc.description.affiliation Univ Fed Sao Paulo, Dept Farmacol, UNIFESP, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, LiNC Dept Psychiat, Brazil UNIFESP, Lab Interdisciplinar Neurociencias Clin, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliation CNPq, INCT TM, Natl Inst Translat Med, Ribeirao Preto, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Farmacol, UNIFESP, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, LiNC Dept Psychiat, Brazil UNIFESP, Lab Interdisciplinar Neurociencias Clin, BR-04039032 Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2010/07994- 3
dc.identifier.doi 10.2174/138161212802884735
dc.description.source Web of Science
dc.identifier.wos WOS:000309512900009



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