The Role of Mitochondrial Function in Glutamate-Dependent Metabolism in Neuronal Cells

The Role of Mitochondrial Function in Glutamate-Dependent Metabolism in Neuronal Cells

Author Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Ureshino, Rodrigo Portes Autor UNIFESP Google Scholar
Rodrigues, L. Autor UNIFESP Google Scholar
Rocha, Katiucha Karolina Autor UNIFESP Google Scholar
Carvalho, J. T. Autor UNIFESP Google Scholar
Oseki, Karen Tubono Autor UNIFESP Google Scholar
Bincoletto, Claudia Autor UNIFESP Google Scholar
Lopes, Guiomar Silva Autor UNIFESP Google Scholar
Hirata, Hanako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Glutamate is an important neurotransmitter in neurons and glial cells and it is one of the keys to the neuron-glial interaction in the brain. Glutamate transmission is strongly dependent on calcium homeostasis and on mitochondrial function. In the present work we presented several aspects related to the role of mitochondria in glutamate signaling and in brain diseases. We focused on glutamate-induced calcium signaling and its relation to the organelle dysfunction with cell death processes. In addition, we have discussed how alterations in this pathway may lead or aggravate a variety of neurodegenerative diseases. We compiled information on how mitochondria can influence cell fate during glutamate stimulation and calcium signaling. These organelles play a pivotal role in neuron and glial exchange, in synaptic plasticity and several pathological conditions related to Aging, Alzheimer's, Parkinson's and Huntington's diseases. We have also presented autophagy as a mechanism activated during mitochondrial dysfunction which may function as a protective mechanism during injury. Furthermore, some new perspectives and approaches to treat these neurodegenerative diseases are offered and evaluated.
Keywords Glutamate
Calcium Signaling
Mitochondrial Dysfunction
Autophagy
Apoptosis
Cell Death
Language English
Date 2011-12-01
Published in Current Pharmaceutical Design. Sharjah: Bentham Science Publ Ltd, v. 17, n. 35, p. 3865-3877, 2011.
ISSN 1381-6128 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 3865-3877
Origin http://dx.doi.org/10.2174/138161211798357782
Access rights Closed access
Type Review
Web of Science ID WOS:000299637300006
URI http://repositorio.unifesp.br/11600/43466

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