The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

Author Schmidt, T. J. Google Scholar
Khalid, S. A. Google Scholar
Romanha, A. J. Google Scholar
Alves, T. M. A. Google Scholar
Biavatti, M. W. Google Scholar
Brun, R. Google Scholar
Da Costa, F. B. Google Scholar
Castro, S. L. de Google Scholar
Ferreira, V. F. Google Scholar
Lacerda, M. V. G. de Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Leon, L. L. Google Scholar
Lopes, N. P. Google Scholar
Amorim, R. C. das Neves Google Scholar
Niehues, M. Google Scholar
Ogungbe, I. V. Google Scholar
Pohlit, A. M. Google Scholar
Scotti, M. T. Google Scholar
Setzer, W. N. Google Scholar
Soeiro, M. de N. C. Google Scholar
Steindel, M. Google Scholar
Tempone, Andre Gustavo Autor UNIFESP Google Scholar
Institution Univ Munster
Universidade Federal de Santa Catarina (UFSC)
Fiocruz MS
Univ Basel
Swiss Trop & Publ Hlth Inst STPH
Universidade de São Paulo (USP)
Fundacao Oswaldo Cruz
Universidade Federal Fluminense (UFF)
Fundacao Med Trop Heitor Vieira Dourado
Universidade Federal de São Paulo (UNIFESP)
Inst Nacl de Pesquisas da Amazonia
Univ Alabama
Univ Fed Paraiba
Adolfo Lutz Inst
Abstract Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen Neglected Tropical Diseases (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given.The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids.In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present.
Keywords Neglected tropical diseases
Trypanosoma
Leishmania
Plasmodium
natural product
lignan
coumarin
caffeic acid
flavonoid
chalcone
aurone
chromene
xanthone
acetogenin
polyacetylene
alkaloid
Language English
Sponsor German Ministry of Science and Education (BMBF)
Date 2012-05-01
Published in Current Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 19, n. 14, p. 2176-2228, 2012.
ISSN 0929-8673 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 2176-2228
Origin http://dx.doi.org/10.2174/092986712800229087
Access rights Closed access
Type Review
Web of Science ID WOS:000303381800006
URI http://repositorio.unifesp.br/11600/43450

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