Motor Neuron Disease and Acquired Axonal Neuropathy Association in HIV Infection: Case Report and Update

Motor Neuron Disease and Acquired Axonal Neuropathy Association in HIV Infection: Case Report and Update

Author Orsini, Marco Google Scholar
Freitas, Marcos R. G. de Google Scholar
Silva, Julio G. Google Scholar
Sohler, Marzia P. Google Scholar
Reis, Carlos H. M. Google Scholar
Catharino, Antonio M. da Silva Google Scholar
Oliveira, Acary Souza Bulle Autor UNIFESP Google Scholar
Machado, Sergio Google Scholar
Nardi, Antonio E. Google Scholar
Salem, Peter Google Scholar
Sztajnbok, Flavio Google Scholar
Leite, Marco A. A. Google Scholar
Nascimento, Cristiane Google Scholar
Davidovich, Eduardo Google Scholar
Porto, Fabio H. de Gobbi Google Scholar
Cruz, Marcia W. Google Scholar
Menezes, Sara L. S. de Google Scholar
Arias-Carrion, Oscar Google Scholar
Institution Universidade Federal Fluminense (UFF)
Hosp Geral Nova Iguacu
Master Program Sci Rehabil UNISUAM
Secretaria Salud Mexico
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Universidade do Estado do Rio de Janeiro (UERJ)
Servidores Hosp State Rio de Janeiro
Universidade de São Paulo (USP)
Univ Salgado de Oliveira
Cent Univ UCEN
Universidade Federal de Uberlândia (UFU)
Abstract Background: A possible viral etiology has been documented in the genesis of motor neuron disorders and acquired peripheral neuropathies, mainly due to the vulnerability of peripheral nerves and the anterior horn to certain viruses. In recent years, several reports show association of HIV infection with Amyotrophic Lateral Sclerosis Syndrome, Motor Neuron Diseases and peripheral neuropathies.Objective: To report a case of an association between Motor Neuron Disease and Acquired Axonal neuropathy in HIV infection, and describe the findings of neurological examination, cerebrospinal fluid, neuroimaging and electrophysiology.Methods: The patient underwent neurological examination. General medical examinations were performed, including, specific neuromuscular tests, analysis of cerebrospinal fluid, muscle biopsy and imaging studies.Results and Discussion: The initial clinical presentation of our case was marked by cramps and fasciculations with posterior distal paresis and atrophy in the left arm. We found electromyography tracings with deficits in the anterior horn of the spinal cord and peripheral nerves. Dysphagia and release of primitive reflexes were also identified. At the same time, the patient was informed to be HIV positive with high viral load. He received antiretroviral therapy, with load control but with no clinical remission.Conclusion: Motor Neuron disorders and peripheral neuropathy may occur in association with HIV infection. However, a causal relationship remains uncertain. It is noteworthy that the antiretroviral regimen may be implicated in some cases.
Keywords Motor neuron disease
HIV infection
acquired neuropathies
Language English
Date 2012-12-01
Published in Current Hiv Research. Sharjah: Bentham Science Publ Ltd, v. 10, n. 8, p. 694-699, 2012.
ISSN 1570-162X (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 694-699
Access rights Closed access
Type Article
Web of Science ID WOS:000311106100010

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