Apathy Is not Associated with Performance in Brief Executive Tests in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease

Apathy Is not Associated with Performance in Brief Executive Tests in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease

Author Guimaraes, Henrique Cerqueira Autor UNIFESP Google Scholar
Fialho, Patricia Paes Google Scholar
Carvalho, Viviane Amaral Google Scholar
Machado, Thais Helena Google Scholar
Santos, Etelvina Lucas Google Scholar
Caramelli, Paulo Google Scholar
Institution Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Abstract Neuropsychological correlates of apathy in Alzheimer's disease (AD) may shed some light on the neurobiology of this behavioral disorder. Whereas previous research has suggested an association between apathy and executive functions in AD, amnestic mild cognitive impairment (aMCI) cohorts point to an association with memory tests. We aimed to further investigate this issue in a sample of low educated, hitherto unexposed to cholinesterase inhibitors, aMCI (n=26) and mild AD (n=28) patients using brief executive tests, namely the Executive Interview (EXIT-25) and the Frontal Assessment Battery (FAB). Patients and controls (n=33) were included from a community-based survey of successful brain aging in Brazilian elderly (75+ years), The Pieta Study. The participants were submitted to a comprehensively neuropsychological assessment and apathy evaluation through the Apathy Scale (AS). We found a strong correlation in AD group between AS scores and functional performance measured by the Disability Assessment in Dementia (rho =-0.7; p<0,001). No association was found between any executive test performance and apathy symptoms. Apathy symptoms were also associated with the performance in memory tests and in the attention subscale of the Mattis Dementia Rating Scale. These findings reinforce the functional effect of apathy even in the mildest stages along the AD cognitive impairment spectrum, and challenges previous assumptions regarding the association between apathy and classical executive functions.
Keywords Alzheimer disease
apathy
executive function
functionality
memory
mild cognitive impairment
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Retired and Pensioner Pavilion from Caete(MG), Brazil
Municipal Health Department
City Hall
Date 2014-01-01
Published in Current Alzheimer Research. Sharjah: Bentham Science Publ Ltd, v. 11, n. 8, p. 792-798, 2014.
ISSN 1567-2050 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 792-798
Origin http://dx.doi.org/10.2174/156720501108140910122509
Access rights Closed access
Type Article
Web of Science ID WOS:000342142600008
URI http://repositorio.unifesp.br/11600/43439

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