Histopathologic study of corneal stromal dystrophies - A 10-year experience

Histopathologic study of corneal stromal dystrophies - A 10-year experience

Author Santos, Leonardo Noleto Negry Autor UNIFESP Google Scholar
Fernandes, Bruno Franco Autor UNIFESP Google Scholar
Moura, Leticia Rielo de Autor UNIFESP Google Scholar
Cheema, Devinder P. Google Scholar
Maloney, Shawn Google Scholar
Logan, Patrick Google Scholar
Burnier Júnior, Miguel Noel Nascente Autor UNIFESP Google Scholar
Institution McGill Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To determine the frequency and describe the histopathologic features of stromal corneal dystrophies over a 10-year period.Methods: A single-centered, retrospective analysis was performed on corneal specimens diagnosed as stromal dystrophies retrieved from the Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a period of 10 years. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin, periodic acid-Schiff, and other special staining.Results: During the period of the study, 885 corneal specimens from penetrating keratoplasties were received. Twenty-six (2.9%) specimens from a total of 22 patients showed stromal corneal dystrophies: 17 (65.4%) eyes with lattice dystrophy, 5 (19.2%) eyes with combined granular/lattice (Avellino) dystrophy, 3 (11.5%) eyes with granular dystrophy, and 1 (3.9%) eye with macular dystrophy.Conclusions: Corneal stromal dystrophies have distinct histopathologic features, which can be diagnosed with routine and special staining, particularly for combined granular/lattice (Avellino) dystrophy. Clinically, combined granular/lattice (Avellino) dystrophy can have features of both lattice and granular dystrophies, which can be misleading for diagnosis. Lattice dystrophy was the most frequent stromal dystrophy in this particular population.
Keywords corneal stromal dystrophies
Language English
Date 2007-10-01
Published in Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 26, n. 9, p. 1027-1031, 2007.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1027-1031
Origin https://dx.doi.org/10.1097/ICO.0b013e318123f298
Access rights Closed access
Type Article
Web of Science ID WOS:000249796400001
URI http://repositorio.unifesp.br/11600/43419

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