A Dynamical Modeling to Study the Adaptive Immune System and the Influence of Antibodies in the Immune Memory

A Dynamical Modeling to Study the Adaptive Immune System and the Influence of Antibodies in the Immune Memory

Author Castro, Alexandre de Autor UNIFESP Google Scholar
Fronza, Carlos Frederico Autor UNIFESP Google Scholar
Alves, Domingos Autor UNIFESP Google Scholar
Institution Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to chall enging problems of modem computing. Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (Lundegaard, Lund, Kesmir, Brunak, Nielsen, 2007). In this article we studied in machina a approach to simulate the process of antigenic mutation and its implications for the process of memory. Our results have suggested that the durability of the immune memory is affected by the process of antigenic mutation.and by populations of soluble antibodies in the blood. The results also strongly suggest that the decrease of the production of antibodies favors the global maintenance of immune memory.
Keywords immune memory
antibodies
B-cells
Language English
Date 2009-05-01
Published in Cmes-computer Modeling In Engineering & Sciences. Norcross: Tech Science Press, v. 45, n. 1, p. 83-96, 2009.
ISSN 1526-1492 (Sherpa/Romeo, impact factor)
Publisher Tech Science Press
Extent 83-96
Origin https://dx.doi.org/10.3970/cmes.2009.045.083
Access rights Closed access
Type Article
Web of Science ID WOS:000269851200004
URI http://repositorio.unifesp.br/11600/43394

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account