Takayasu arteritis in a Brazilian multicentre study: children with a longer diagnosis delay than adolescents

Takayasu arteritis in a Brazilian multicentre study: children with a longer diagnosis delay than adolescents

Author Clemente, Gleice Autor UNIFESP Google Scholar
Hilário, Maria Odete Esteves Autor UNIFESP Google Scholar
Lederman, Henrique Manoel Autor UNIFESP Google Scholar
Silva, C. A. Google Scholar
Sallum, A. M. Google Scholar
Campos, L. M. Google Scholar
Sacchetti, S. Google Scholar
Santos, M. C. dos Google Scholar
Ferriani, Virginia Paes Leme Autor UNIFESP Google Scholar
Sztajnbok, F. Google Scholar
Gasparello, R. Google Scholar
Oliveira, S. Knupp Google Scholar
Lessa, M. Google Scholar
Bica, B. Google Scholar
Cavalcanti, A. Google Scholar
Robazzi, T. Google Scholar
Bandeira, M. Google Scholar
Terreri, Maria Teresa Ramos Ascensão Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Santa Casa Misericordia Sao Paulo
Universidade do Estado do Rio de Janeiro (UERJ)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de Pernambuco (UFPE)
Universidade Federal da Bahia (UFBA)
Hosp Pequeno Principe
Abstract Objective. To evaluate and compare demographic, clinical, laboratory and angiographic data of Brazilian children and adolescents with Takayasu's arteritis.Methods. In this Brazilian multicentre, retrospective study which included 10 paediatric rheumatology centres, we identified 71 children and adolescents with Takayasu's arteritis which were diagnosed before their 19th birthday. The patients' demographic, clinical, laboratorial and angiographic data were recorded. The participants were divided into two groups: children, defined by the WHO as younger than 10 years old (group 1: 36 patients) and adolescents, defined as individuals aged 10 to 19 years old (group 2: 35 patients). Features of both groups concerning disease manifestations were compared.Results. A total of 21 (58.3%) patients in group 1 and 30 (85.7%) patients in group 2 were girls (p=0.01). The mean age at disease onset, the mean time to diagnosis, and the mean follow-up time were 5.7 and 12.7, 1.8 and 0.7, 7.2 and 3.6 years, respectively, in groups 1 and 2 (p<0.001, 0.001 and <0.001). At initial evaluation, constitutional symptoms (77.5%) were the most predominant symptoms and decreased peripheral pulses (85.9%) was the most predominant clinical sign without differences between groups. The main laboratory findings were increased erythrocyte sedimentation rate followed by leukocytosis. Anaemia, thrombocytosis and higher platelet levels were significantly more frequent in group 1 (p=0.031, 0.001 and 0.018). Angiographic data were similar in both groups.Conclusion. Children presented more laboratory abnormalities but clinical and angio graphic characteristics were similar to those presented by the adolescents. Diagnosis delay is longer in younger patients.
Keywords Takayasu arteritis
vasculitis
child
adolescent
diagnosis
angiography
Language English
Date 2014-05-01
Published in Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 32, n. 2, p. S128-S133, 2014.
ISSN 0392-856X (Sherpa/Romeo, impact factor)
Publisher Clinical & Exper Rheumatology
Extent S128-S133
Origin http://www.clinexprheumatol.org/abstract.asp?a=7199
Access rights Closed access
Type Article
Web of Science ID WOS:000337069400025
URI http://repositorio.unifesp.br/11600/43338

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