Sudden unexpected death in an adolescent with epilepsy: All roads lead to the heart?

Sudden unexpected death in an adolescent with epilepsy: All roads lead to the heart?

Author Pinto, Kylvia G. F. D. Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Martins, Luciana D. Google Scholar
Machado, Helio R. Google Scholar
Sakamoto, Américo Ceiki Autor UNIFESP Google Scholar
Terra, Vera C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The incidence of sudden unexpected death in epilepsy (SUDEP) has been estimated from 0.5-1.4/1,000 person-years in people with treated epilepsy, and 9/1,000 person-years in candidates for epilepsy surgery. Potential risk factors for SUDEP include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure type and winter temperatures. The arrythmogenic side-effect of antiepileptic drugs and seizures may increase the risk of SUDEP. In this report, we describe a patient with prolonged post-ictal tachycardia in EEG video recordings with a typical case of SUDEP: a 16-year-old boy with medically intractable complex partial seizures. Magnetic resonance imaging revealed left mesial temporal sclerosis. During non-invasive video-EEG monitoring, the patient presented a post-ictal heart rate increased for five hours. Two months after video-EEG, he died from SUDEP during a tonic-clonic secondary generalized seizure. The possibility of cardiac involvement in the pathogenesis of SUDEP has been suggested by many studies. Evaluation of this patient with EEG-video monitoring, including measurement of heart rate, contributed to an identification of ictal tachycardia that may have played a role in the SUDEP. Premature mortality seems to be increased in patients with epilepsy, and cardiac abnormalities may be a possible cause of SUDEP. (Cardiol J 2011; 18, 2: 194-196)
Keywords sudden death
epilepsy
EEG
heart
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
INCT/MCT
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-03-01
Published in Cardiology Journal. Gdansk: Via Medica, v. 18, n. 2, p. 194-196, 2011.
ISSN 1897-5593 (Sherpa/Romeo, impact factor)
Publisher Via Medica
Extent 194-196
Origin https://journals.viamedica.pl/cardiology_journal/article/view/21274/16878
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000293941000014
URI http://repositorio.unifesp.br/11600/43252

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