Ethnic differences in serum pepsinogen levels among Japanese and non-Japanese Brazilian gastric cancer patients and controls

Ethnic differences in serum pepsinogen levels among Japanese and non-Japanese Brazilian gastric cancer patients and controls

Author Fahey, M. T. Google Scholar
Hamada, G. S. Google Scholar
Nishimoto, I. N. Google Scholar
Kowalski, Luiz Paulo Autor UNIFESP Google Scholar
Iriya, K. Google Scholar
Gama-Rodrigues, J. J. Google Scholar
Tsugane, S. Google Scholar
Institution Natl Canc Ctr
Universidade Federal de São Paulo (UNIFESP)
AC Camargo Hosp
Universidade de São Paulo (USP)
Abstract A low level of serum pepsinogen I (Pg I) is a risk factor for gastric cancer (GC); low levels of Pg I and the pepsinogen ratio (Pg I:Pg II) are correlated with chronic atrophic gastritis. We report serum Pg levels and compare the degree of association with GC among Japanese and non-Japanese Brazilians. Sera were cross-sectionally ascertained from 93 Japanese Brazilian patients category matched by age and sex with 110 controls, and 228 non-Japanese Brazilian patients individually matched by age and sex with one control. Among non-Japanese Brazilians, GC was associated with a Pg I level <30 ng/ml (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.7-3.8) and a Pg I:Pg II ratio <3.0 (OR, 3.3; 95% CI, 2.2-5.3). However, among Japanese Brazilians, the association was present with a level of Pg I <30 ng/ml (OR, 3.5; 95% CI, 1.9-6.3), and was weak with a Pg I:PZ: II ratio <3.0 (OR, 1.3; 95% CI, 0.73-2.4). Serum Pg I may be preferred to the Pg I:Pg II ratio to study the association between Pg and GC among Japanese Brazilians.
Keywords pepsinogen
stomach neoplasms
Brazil
ethnicity
Japan
serology
Language English
Date 2000-01-01
Published in Cancer Detection And Prevention. Sudbury: Jones And Bartlett Publishers, v. 24, n. 6, p. 564-571, 2000.
ISSN 0361-090X (Sherpa/Romeo, impact factor)
Publisher Jones And Bartlett Publishers
Extent 564-571
Origin https://www.ncbi.nlm.nih.gov/pubmed/11198270
Access rights Closed access
Type Article
Web of Science ID WOS:000166173600008
URI http://repositorio.unifesp.br/11600/43240

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