Effect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive rats

Effect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive rats

Author Silva, Eneida de Gusmao Autor UNIFESP Google Scholar
Fredianineto, E. Google Scholar
Ferreira, A. T. Google Scholar
Autor UNIFESP Google Scholar
Paiva, Therezinha Bandiera Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1 The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NWR) was supplemented with 12.5 mu g cholecalciferol per 100 g body weight daily, by gavage, for 4 weeks.2 The amplitude of the contractile responses of aortic rings from SHR to potassium and adrenaline, which was smaller than in NWR aortae, was increased after treatment with cholecalciferol. No further changes were observed in the responses of NWR and SHR aortae in the presence of 100 nM apamin.3 The membrane potentials of aortae from SHR, which were higher than those of aortae from NWR, decreased after treatment with cholecalciferol. Further depolarization was observed in aortic rings from NWR, but not in aortic rings from SHR, after their preincubation with 100 nM apamin.4 It is concluded that cholecalciferol normalizes the membrane potential and contractility of aortae from SHR, probably through an effect on lipid composition and structure of the plasma membrane.
Keywords cholecalciferol
spontaneously hypertensive rats
aorta
membrane potential
contraction
Language English
Date 1996-07-01
Published in British Journal Of Pharmacology. Basingstoke: Stockton Press, v. 118, n. 6, p. 1367-1370, 1996.
ISSN 0007-1188 (Sherpa/Romeo, impact factor)
Publisher Stockton Press
Extent 1367-1370
Origin http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1996.tb15546.x/full
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1996UY15700006
URI http://repositorio.unifesp.br/11600/43180

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