Betahistine in the treatment of tinnitus in patients with vestibular disorders

Betahistine in the treatment of tinnitus in patients with vestibular disorders

Alternative title Betaistina no tratamento do zumbido em pacientes com distúrbios vestibulares
Author Ganança, Mauricio Malavasi Autor UNIFESP Google Scholar
Caovilla, Heloisa Helena Autor UNIFESP Google Scholar
Gazzola, Juliana Maria Google Scholar
Gananca, Cristina Freitas Autor UNIFESP Google Scholar
Ganança, Fernando Freitas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Bandeirante Sao Paulo
Abstract Betahistine is a medicine used to treat vestibular disorders that has also been used to treat tinnitus.Aim: To assess the effects of betahistine on tinnitus in patients with vestibular disorders.Material and method: Retrospective data were collected from patient records for individuals presenting with vestibular dysfunction and tinnitus. Patients included had received betahistine 48 mg/day and clinical outcomes were compared with a control group comprising individuals who were unable to receive betahistine due to gastritis, ulcers, pregnancy, asthma or hypersensitivity to the drug. Patients underwent control of any aggravating factors and also standard vestibular exercises as a basis for treatment. The intensity, frequency and duration of tinnitus were assessed on the first day of dosing and after 120 days of treatment. Clinical improvement was defined as a total or partial reduction of tinnitus after treatment.Results: Clinical improvement was observed in 80/262 (30.5%) of patients treated with betahistine and 43/252 (17.1%) of control patients. Betahistine significantly (p<0.0001) improved tinnitus in treated individuals.Conclusion: The daily dosage of 48 mg of betahistine during 120 consecutive days is useful to reduce or eliminate tinnitus in patients with vestibular disorders.
Keywords dizziness
medication therapy
Language English
Date 2011-07-01
Published in Brazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 77, n. 4, p. 499-503, 2011.
ISSN 1808-8694 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
Extent 499-503
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000293863600014
SciELO ID S1808-86942011000400014 (statistics in SciELO)

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