Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

Author Brum, P. C. Google Scholar
Bacurau, A. V. N. Google Scholar
Medeiros, A. Autor UNIFESP Google Scholar
Ferreira, J. C. B. Google Scholar
Vanzelli, A. S. Google Scholar
Negrao, C. E. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Abstract Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.
Keywords Heart failure
Exercise training
Sympathetic hyperactivity
Ventricular function
Cardiac remodeling
Skeletal myopathy
Language English
Date 2011-09-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 44, n. 9, p. 827-835, 2011.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 827-835
Origin http://dx.doi.org/10.1590/S0100-879X2011007500075
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000295721500002
SciELO ID S0100-879X2011000900002 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/43136

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