Transfer of IgG subclasses across placenta in term and preterm newborns

Transfer of IgG subclasses across placenta in term and preterm newborns

Author Costa Carvalho, B. T. Google Scholar
Vieira, H. M. Google Scholar
Dimantas, RBR Google Scholar
Arslanian, C. Google Scholar
Naspitz, Charles Kirov Autor UNIFESP Google Scholar
Solé, Dirceu Autor UNIFESP Google Scholar
CarneiroSampaio, MMS Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract In order to study placental transfer of IgG subclasses, paired blood samples were collected from mothers and umbilical cord of preterm (N = 69) and full-term (N = 68) newborns. The full-term group was further divided into 3 subgroups: appropriate for gestational age (AGA, N = 43), large for gestational age (LGA, N = 13) and small for gestational age (SGA, N = 12), according to birth weight. IgC subclasses (IgG1, IgG2, IgG3 and IgG4) were measured by the single radial immunodiffusion technique using monoclonal antibodies. IgG1 and IgG3 newborn subclass concentrations (10.17 and 0.57 g/l, respectively) increased with increasing gestational age and reached maternal levels (IgG1 = 8.86; IgG3 = 0.67 g/l) during the 37th week of pregnancy. Low levels of these subclasses were found in premature newborns. IgG2 from newborns were always lower than maternal levels (P<0.05). LGA and SGA newborns had equivalent levels of IgG1 and IgG2 compared with AGA. SGA newborns had higher levels of lgG3 and lower levels of IgG4 than LGA and AGA newborns.
Keywords preterm newborn
passive immunity
Language English
Date 1996-02-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 29, n. 2, p. 201-204, 1996.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 201-204
Access rights Closed access
Type Article
Web of Science ID WOS:A1996TV30300005

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