Antinociceptive effect of purine nucleotides

Antinociceptive effect of purine nucleotides

Author Mello, C. F. Google Scholar
Begnini, J. Google Scholar
DeLaVega, D. D. Google Scholar
Lopes, F. P. Google Scholar
Schwartz, C. C. Google Scholar
JimenezBernal, R. E. Google Scholar
Bellot, Rogerio Gentil Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The antinociceptive effect of purine nucleotides administered systemically (sc) was determined using the formalin and writhing tests in adult male albino mice. The mechanisms underlying nucleotide-induced antinociception were investigated by preinjecting the animals (sc) with specific antagonists for opioid (naloxone, 1 mg/kg), purinergic P-1 (caffeine, 5, 10 or 30 mg/kg); theophylline, 10 mg/kg) or purinergic P-2 receptors (suramin, 100 mg/kg, Coomassie blue, 30-300 mg/kg; quinidine, 10 mg/kg). Adenosine, adenosine monophosphate (AMP), diphosphate (ADP) and triphosphate (ATP) caused a reduction in the number of writhes and in the time of licking the formalin-injected paw. Naloxone had no effect on adenosine- or adenine nucleotide-induced antinociception. Caffeine (30 mg/kg) and theophylline (10 mg/kg) reversed the antinociceptive action of adenosine and adenine nucleotide derivatives in both tests. P-2 antagonists did not reverse adenine nucleotide-induced antinociception. These results suggest that the antinociceptive effect of adenine nucleotides is mediated by adenosine.
Keywords ATP
purinergic transmission
adenosine
antinociception
methylxanthines
caffeine
theophylline
inflammatory response
anti-inflammatory agents
P-1 receptors
P-2 receptors
Language English
Date 1996-10-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 29, n. 10, p. 1379-1387, 1996.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 1379-1387
Access rights Closed access
Type Article
Web of Science ID WOS:A1996VM71000020
URI http://repositorio.unifesp.br/11600/43096

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