ASSESSMENT OF GLOMERULAR-FILTRATION RATE UTILIZING SUBCUTANEOUSLY INJECTED CR-51-EDTA

ASSESSMENT OF GLOMERULAR-FILTRATION RATE UTILIZING SUBCUTANEOUSLY INJECTED CR-51-EDTA

Author Monteiro, MCA Google Scholar
Alonso, Gilberto Autor UNIFESP Google Scholar
Ajzen, Horacio Autor UNIFESP Google Scholar
Pereira, A. B. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1. Cr-51-EDTA injected with lidocaine and epinephrine, as a subcutaneous button, is slowly absorbed, and a plasma level that is relatively stable can be maintained for a time sufficient to permit measurement of the renal clearance of EDTA, which is a measure of glomerular filtration rate (GFR). We studied this procedure in 32 normal volunteers and 24 patients with different glomerulopathies, comparing EDTA and creatinine clearances. In 20 patients these measurements were also compared with inulin clearance.2. Creatinine clearance overestimates GFR due to tubular secretion of creatinine. This secretion is present even in patients with significantly reduced glomerular filtration rates. As a consequence, the lower the GFR the higher the overestimation will be.3. A good correlation was obtained between the Cr-51-EDTA and inulin clearance: y(EDTA) = 4.21 + 0.88 x (inulin), r = 0.98. The procedure is simple to perform, and the radiotracer utilized is significantly less expensive than iothalamate.
Keywords CR-51-EDTA
GLOMERULAR FILTRATION RATE (GFR)
KIDNEY FUNCTION
INULIN CLEARANCE
CREATININE CLEARANCE
Language English
Date 1994-11-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 11, p. 2557-2564, 1994.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 2557-2564
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PQ37600007
URI http://repositorio.unifesp.br/11600/43049

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