BLOOD-GLUCOSE AND INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE BY PATIENTS WITH CHRONIC CHAGAS-DISEASE AND ALCOHOLISM

BLOOD-GLUCOSE AND INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE BY PATIENTS WITH CHRONIC CHAGAS-DISEASE AND ALCOHOLISM

Author Oliveira, LCM Google Scholar
Juliano, Yara Autor UNIFESP Google Scholar
Novo, Neil Ferreira Autor UNIFESP Google Scholar
Neves, Manoel Martins das Autor UNIFESP Google Scholar
Institution Universidade Federal de Uberlândia (UFU)
Universidade Federal de São Paulo (UNIFESP)
Abstract Blood glucose and insulin responses to intravenous glucose 500 mg/kg in a group of alcoholic chagasic patients (Group I, N = 15) were assessed and compared to those of a group of patients with Chagas' disease without alcoholism (Group II, N = 16), a group of alcoholics without Chagas' disease (Group III, N = 22), and a group of non-alcoholics without Chagas' disease (Group IV, N = 15). Determinations of serum glucose and insulin were done under fasting conditions, 5 and 10 min after the injection of 50% glucose. There was no difference in mean serum glucose levels between groups. Mean serum insulin levels at times 5 and 10 min and for the total integrated response were lower (P<0.05) in Groups I and II as compared to Group IV; at time 10 min the mean was lower (P<0.05) in Group III as compared to Group IV. There was a nonsignificant trend for a lower insulinemic response in Group I as compared to Group II. These data suggest denervation of or injury to pancreatic B cell by Chagas' disease.
Keywords BLOOD GLUCOSE
BLOOD INSULIN
ALCOHOLISM
AMERICAN TRYPANOSOMIASIS
CHAGAS DISEASE
Language English
Date 1993-11-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 26, n. 11, p. 1187-1190, 1993.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 1187-1190
Access rights Closed access
Type Article
Web of Science ID WOS:A1993MG75900006
URI http://repositorio.unifesp.br/11600/43032

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