EFFECTS OF A SINGLE ADMINISTRATION OF BUSPIRONE ON CATALEPSY, YAWNING AND STEREOTYPY IN RATS

EFFECTS OF A SINGLE ADMINISTRATION OF BUSPIRONE ON CATALEPSY, YAWNING AND STEREOTYPY IN RATS

Author Conceição, Isaltino Marcelo da Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract In the present study, the effects of a single administration of buspirone (0. 1, 0.3, 1.0, and 3.0 mg/kg sc-30 min before testing) on three dopamine-related behaviors were evaluated in 4-month old male Wistar rats (7-10 animals per group). Buspirone decreased haloperidol (2.0 mg/kg ip)-induced catalepsy in a dose-dependent manner (from 7.30 to 5.09 In of s compared to the untreated control group). Apomorphine (0-06 mg/kg sc)-induced yawning was also dose-dependently reduced (from 26.7 to 0.9 yawns in 30 min) and so was apomorphine (1.0 mg/kg sc)-induced stereotypy (from 32.9 to 5.9, sum of scores). The present results indicate that buspirone presents unique pharmacological effects related to dopaminergic transmission not only in biochemical but also in behavioral terms.
Keywords BUSPIRONE
CATALEPSY
YAWNING
STEREOTYPY
Language English
Date 1993-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 26, n. 1, p. 71-74, 1993.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 71-74
Access rights Closed access
Type Article
Web of Science ID WOS:A1993KP41900008
URI http://repositorio.unifesp.br/11600/43030

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