ANTITUMOR EFFECTS OF DOPAMINERGIC BLOCKERS IN MICE BEARING EHRLICH TUMORS

ANTITUMOR EFFECTS OF DOPAMINERGIC BLOCKERS IN MICE BEARING EHRLICH TUMORS

Author Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Soares, CGC Google Scholar
Decio, R. C. Google Scholar
Francischetti, I Google Scholar
Haber, V. A. Google Scholar
Onimaru, A. T. Google Scholar
Institution FDN MUNICIPAL ENSINO SUPER MARILIA
Universidade Federal de São Paulo (UNIFESP)
Abstract We determined the effect of 13 days of treatment with 2.0 mg/kg haloperidol, 30.0 mg/kg metoclopramide or 4.0 mg/kg domperidone on the number of tumor cells of mice bearing Ehrlich ascites carcinoma. The three dopaminergic blockers significantly reduced the number of tumor cells of experimental mice. The mean +/- SEM number of tumor cells x 10(6) ml saline lavage was 25.5 +/- 5.9 for the haloperidol group, 36.8 +/- 4.7 for the metoclopramide group, 25.3 +/- 3.5 for the domperidone group and 54.0 +/- 9.0 for the control mice (treated with 0.9% NaCl). In a second experiment, treatment with 0.5 and 2.0 mg/kg haloperidol showed that the antitumor effect of this drug was dose dependent. The possible mechanisms underlying these results (such as an increase in prolactin levels or a direct action of these drugs on lymphocytes) are discussed in light of the specific pharmacological properties of each dopaminergic blocker.
Keywords HALOPERIDOL
METOCLOPRAMIDE
DOMPERIDONE
EHRLICH ASCITES CARCINOMA
ANTITUMOR THERAPY
Language English
Date 1991-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 6, p. 611-614, 1991.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 611-614
Access rights Closed access
Type Article
Web of Science ID WOS:A1991GC18700011
URI http://repositorio.unifesp.br/11600/43006

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