ANDROGEN REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR-IONIC CHANNEL IN A HORMONE-DEPENDENT SKELETAL-MUSCLE

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dc.contributor.author Souccar, Caden [UNIFESP]
dc.contributor.author Yamamoto, Lucia Akie [UNIFESP]
dc.contributor.author Goncalo, M. C.
dc.contributor.author Lapa, Antonio José [UNIFESP]
dc.date.accessioned 2018-06-15T14:28:00Z
dc.date.available 2018-06-15T14:28:00Z
dc.date.issued 1991-01-01
dc.identifier.citation Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 10, p. 1051-1054, 1991.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/11600/42996
dc.description.abstract The trophic influence of testosterone on the nicotinic acetylcholine receptor-ionic channel (AChR) was studied in the levator ani (LA) muscle of adult male rats (120 days) intact (C) or gonadectomized when 90 days old (G). In the indirectly elicited muscle twitch, the LA from G rats was less sensitive to d-tubocurarine (0.1-1-mu-M) than control muscles (IC25: C = 0.30-mu-M, G = 0.46-mu-M). In G rats, the amplitude of neurally evoked endplate currents (EPC) was reduced by 70%, but the EPC time constant was not changed. Maximal junctional binding of [I-125]alpha-bungarotoxin in the LA (C: 72.5 +/- 13.2 amol/endplate) was reduced by 1.8-fold in LA from G rats, with no change of the association rate constant (C: 5.64 +/- 1.29 10(6) M-1 min-1). The results indicate that testosterone deprivation reduces the junctional AChR density in the rat LA without modifying the binding properties of the receptor. en
dc.format.extent 1051-1054
dc.language.iso eng
dc.publisher Assoc Bras Divulg Cientifica
dc.relation.ispartof Brazilian Journal Of Medical And Biological Research
dc.rights Acesso restrito
dc.subject LEVATOR ANI MUSCLE en
dc.subject TESTOSTERONE en
dc.subject ACETYLCHOLINE RECEPTOR en
dc.subject END-PLATE CURRENTS en
dc.subject D-TUBOCURARINE en
dc.subject ALPHA-BUNGAROTOXIN en
dc.title ANDROGEN REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR-IONIC CHANNEL IN A HORMONE-DEPENDENT SKELETAL-MUSCLE en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED SCH,DEPT FARMACOL,DISCIPLINA FARMACOL CELULAR,RUA TRES MAIO 100,BR-04044 SAO PAULO,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,DEPT FARMACOL,DISCIPLINA FARMACOL CELULAR,RUA TRES MAIO 100,BR-04044 SAO PAULO,BRAZIL
dc.description.source Web of Science
dc.identifier.wos WOS:A1991GR20300010



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