Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia

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dc.contributor.author Brandao, Leticia de Campos [UNIFESP]
dc.contributor.author Hachul, Helena [UNIFESP]
dc.contributor.author Bittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.author Baracat, Edmund Chada [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author D'Almeida, Vania [UNIFESP]
dc.date.accessioned 2018-06-15T14:04:25Z
dc.date.available 2018-06-15T14:04:25Z
dc.date.issued 2009-01-01
dc.identifier http://dx.doi.org/10.4067/S0716-97602009000300002
dc.identifier.citation Biological Research. Santiago: Soc Biolgia Chile, v. 42, n. 3, p. 281-287, 2009.
dc.identifier.issn 0716-9760
dc.identifier.uri http://repositorio.unifesp.br/11600/42822
dc.description.abstract Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total gluthathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress Status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship AFIP FADA-UNIFESP
dc.description.sponsorship Zambon Group
dc.format.extent 281-287
dc.language.iso eng
dc.publisher Soc Biolgia Chile
dc.relation.ispartof Biological Research
dc.rights Acesso aberto
dc.subject homocysteine en
dc.subject isoflavones en
dc.subject insomnia en
dc.subject menopause en
dc.subject oxidative stress en
dc.title Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, EPM, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, EPM, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, EPM, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, EPM, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, EPM, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, EPM, Dept Biosci, Sao Paulo, Brazil
dc.identifier.file S0716-97602009000300002.pdf
dc.identifier.scielo S0716-97602009000300002
dc.identifier.doi 10.4067/S0716-97602009000300002
dc.description.source Web of Science
dc.identifier.wos WOS:000270893400002



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