Placental antibody transfer: influence of maternal HIV infection and placental malaria

Placental antibody transfer: influence of maternal HIV infection and placental malaria

Author Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Verhoeff, F. Google Scholar
Chimsuku, L. Google Scholar
Milligan, PJM Google Scholar
Wesumperuma, L. Google Scholar
Broadhead, R. L. Google Scholar
Brabin, B. J. Google Scholar
Johnson, P. M. Google Scholar
Hart, C. A. Google Scholar
Institution Univ Liverpool
Universidade Federal de São Paulo (UNIFESP)
Queen Elizabeth Cent Hosp
Abstract Aim-To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer.Methods-One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG antibody titres using nephelometry, and for specific Ige antibody titres to Streptococcus pneumoniae, measles, and tetanus toroid antibodies using an enzyme linked immunsorbent assay (ELISA).Results-Multiple regression analyses showed that placental malaria was associated with a decrease in placental IgG antibody transfer to S pneumoniae sand measles to 82% and 81%, respectively. Maternal HIV infection was associated with a reduction in IgG antibody transfer to S pneumoniae to 79%; raised maternal total serum IgG titres were correlated with S pneumoniae and measles IgG antibody transfer reduction to 86% and 87%, respectively. No effect was seen with tetanus toroid antibody transfer.Conclusion-The combined influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia seems to be linked to the low transplacental antibody transfer observed in the Malawian population.
Keywords malaria
HIV
antibody transfer
S pneumoniae
Language English
Date 1998-11-01
Published in Archives Of Disease In Childhood. London: British Med Journal Publ Group, v. 79, n. 3, p. F202-F205, 1998.
ISSN 0003-9888 (Sherpa/Romeo, impact factor)
Publisher British Med Journal Publ Group
Extent F202-F205
Origin http://dx.doi.org/10.1136/fn.79.3.F202
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000076694500009
URI http://repositorio.unifesp.br/11600/42645

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account