Histogenesis of the acquired cystic kidney disease - An immunohistochemical study

Histogenesis of the acquired cystic kidney disease - An immunohistochemical study

Author Costa, Maria Zelia de Oliveira Autor UNIFESP Google Scholar
Bacchi, Carlos Eduardo Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Israeli Albert Einstein Hosp
Abstract The aim of this study was to characterize by immunohistochemistry the histogenesis of cysts in acquired cystic kidney disease (ACKD). Thirty renal tissues fixed in 10% formalin and embedded in paraffin from 20 cases of ACKD were studied. Vimentin was used to stain the Bowman's capsule epithelium, Lotus tetragonolobus agglutinin (LTA) and Leu M1 (CD 15) for proximal tubules; Tamm-Horsfall protein (THP) for distal tubules; epithelial membrane antigen (EMA), cytokeratin 19 (CK19), Arachis hypogea agglutinin (PNA), and Glycine maximum agglutinin (SBA) for distal tubules and collecting ducts; and Ulex ettropaeus agglutinin (UEA-I) and Dolichos biflorus agglutinin (DBA) for collecting ducts. A histologically normal kidney, free of cystic disease, was used as a control for all the markers. Most of the cysts showed strong reactivity to LTA and CD15, an immunophenotype more characteristic of proximal tubules.
Keywords acquired cystic kidney disease
histogenesis
inummohistochemistry
lectins
Language English
Date 2006-09-01
Published in Applied Immunohistochemistry & Molecular Morphology. Philadelphia: Lippincott Williams & Wilkins, v. 14, n. 3, p. 348-352, 2006.
ISSN 1062-3345 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 348-352
Origin http://journals.lww.com/appliedimmunohist/pages/articleviewer.aspx?year=2006&issue=09000&article=00015&type=abstract
Access rights Closed access
Type Article
Web of Science ID WOS:000240072600015
URI http://repositorio.unifesp.br/11600/42615

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