Demyelinating disease in patients with myasthenia gravis

Demyelinating disease in patients with myasthenia gravis

Alternative title Doenças desmielinizantes em pacientes com miastenia gravis
Author Bichuetti, Denis Bernardi Autor UNIFESP Google Scholar
Barros, Tatiane Martins de Autor UNIFESP Google Scholar
Oliveira, Enedina Maria Lobato de Autor UNIFESP Google Scholar
Annes, Marcelo Autor UNIFESP Google Scholar
Gabbai, Alberto Alain Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Bayer Schering Pharma do Brasil
Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by fluctuating muscle weakness, caused by impaired neuromuscular transmission. Patients with MG can present other autoimmune diseases in association, commonly hypo or hyperthyroidism. The association of MG to demyelinating disease is rare and has been described before. We report on three Brazilian patients with MG that presented distinct demyelinating diseases, two monophasic and one recurrent neuromyelitis optica, several years after the diagnosis of MG, and discuss their clinical courses.

Miastenia gravis (MG) é doença autoimune caracterizada por episódios de fraqueza muscular alternados com melhora, causada por bloqueio da junção neuromuscular. Pacientes com MG podem apresentar outras doenças autoimunes, comumente hipo ou hipertiroidismo, e a associação de MG com doenças desmielinizantes é raramente descrita. Relatamos três pacientes brasileiros com MG que desenvolveram doenças desmielinizantes, dois monofásicos e um neuromielite óptica recorrente, vários anos após o diagnóstico de MG e discutimos seus cursos clínicos.
Keywords myasthenia gravis
myelinating disease
association
miastenia gravis
doenças desmielinizante
associação
Language English
Date 2008-03-01
Published in Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 1, p. 5-7, 2008.
ISSN 0004-282X (Sherpa/Romeo)
Publisher Academia Brasileira de Neurologia - ABNEURO
Extent 5-7
Origin http://dx.doi.org/10.1590/S0004-282X2008000100002
Access rights Open access Open Access
Type Article
SciELO ID S0004-282X2008000100002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/4259

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