PREVENTION OF ASTHMA BY KETOTIFEN IN INFANTS WITH ATOPIC-DERMATITIS

PREVENTION OF ASTHMA BY KETOTIFEN IN INFANTS WITH ATOPIC-DERMATITIS

Author Iikura, Y. Google Scholar
Naspitz, Charles Kirov Autor UNIFESP Google Scholar
Mikawa, H. Google Scholar
Talarico Filho, Sergio Autor UNIFESP Google Scholar
Baba, M. Google Scholar
Sole, Diceu Autor UNIFESP Google Scholar
Nishima, S. Google Scholar
Institution NATL PEDIAT HOSP
Universidade Federal de São Paulo (UNIFESP)
KYOTO UNIV
DOI MEM HOSP
NATL MINAMI FUKUOKA HOSP
Abstract To evaluate the prophylactic effect of ketotifen against the onset of asthma we selected 121 infants with atopic dermatitis, without any history suggestive of asthma (cough and/or wheezing). Sixty-one children received ketotifen twice daily. Those who weighted less than 14 kg received 0.8 mg; 14 kg or more, 1.2 mg. Sixty children, a placebo syrup indistinguishable from the active syrup. Both groups, were followed for 1 year, with bimonthly evaluations. The criteria for onset of asthma were two different episodes of wheezing treated with bronchodilator drugs. Both groups were comparable regarding age, sex, weight, onset, and duration of atopic dermatitis and age at the onset of asthma. During the 1 year study, asthma was observed in eight children of the ketotifen group (13.1%) and in 25 children of the placebo group (41.6%) (P < .001). Side effects were negligible and routine laboratory tests disclosed no significant alterations. Ketotifen is a very useful drug for prevention of asthma in children with atopic dermatitis and total IgE more than 50 IU/mL.
Language English
Date 1992-03-01
Published in Annals Of Allergy. Arlington Hts: Amer Coll Allergy Asthma Immunology, v. 68, n. 3, p. 233-236, 1992.
ISSN 0003-4738 (Sherpa/Romeo, impact factor)
Publisher Amer Coll Allergy Asthma Immunology
Extent 233-236
Access rights Closed access
Type Article
Web of Science ID WOS:A1992HK26000007
URI http://repositorio.unifesp.br/11600/42561

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