Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns

Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns

Author Guerra-Shinohara, Elvira Maria Google Scholar
Morita, Olga E. Google Scholar
Peres, Sabrina Google Scholar
Pagliusi, Regina A. Google Scholar
Sampaio Neto, Luiz Ferraz de Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Irazusta, Silvia P. Google Scholar
Allen, Robert H. Google Scholar
Stabler, Sally P. Google Scholar
Institution Universidade de São Paulo (USP)
Inst Pesquisas Secretaria Saude Estado Sao Paulo
Inst Adolfo Lutz Registro
Universidade Federal de São Paulo (UNIFESP)
Secretaria Saude Estado Sao Paulo
Univ Colorado
Abstract Background: Pregnant women with low cobalamin concentrations are unable to provide the necessary amount of cobalamin to their fetuses. The effect of low maternal cobalamin concentrations on transmethylation metabolism in pregnant women and their newborns is unknown.Objective: We investigated the relation between maternal and neonatal cobalamin concentrations and changes in total homocysteine (tHcy), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH).Design: Hematologic data and concentrations of cobalamin, red blood cell folate, serum folate, tHcy, methylinalonic acid, SAM, SAH, and other metabolites were measured in 119 serum specimens from pregnant Brazilian women (gestational age: 37-42 wk) and their newborns' placental veins at the time of delivery.Results: The tHcy concentrations were higher in placental vein serum from newborns whose mothers had low cobalamin. Serum SAH concentrations were elevated and serum SAM and methionine concentrations were decreased in pregnant women with lower cobalamin concentrations. SAM:SAH was significantly decreased in both cobalamin-deficient pregnant women and their newborns.Conclusions: Lower maternal cobalamin concentrations are associated with higher tHcy and lower SAM:SAH in newborns. Because SAM:SAH is closely linked with the activity of numerous enzymatic methylation reactions, these results suggest that methylation could be impaired in cobalamin-deficient pregnant women and their newborns.
Keywords cobalamin
folate
homocysteine
methylmalonic acid
S-adenosylhomocysteine
S-adenosylmethionine
pregnant women
newborns
Language English
Date 2004-11-01
Published in American Journal Of Clinical Nutrition. Bethesda: Amer Soc Clinical Nutrition, v. 80, n. 5, p. 1312-1321, 2004.
ISSN 0002-9165 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Clinical Nutrition
Extent 1312-1321
Origin http://ajcn.nutrition.org/content/80/5/1312.full
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000225036000029
URI http://repositorio.unifesp.br/11600/42267

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